RT期刊文章SR电子T1没有皮质病变的MRI证据neuromyelitis视摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP 1671 OP 1676 10.1半岛投注体育官网212 / WNL。0 b013e31826e9a96 VO 79是16 A1 Massimiliano花茎甘蓝A1孙小姐哦A1爱丽丝Favaretto A1弗朗西斯卡里纳尔蒂A1瓦伦蒂娜Poretto A1萨拉塞A1 Byung-Chul李A1庆浩Yu A1 Hyeo-Il马A1 Paola Perini A1保罗·盖洛年2012 UL //www.ebmtp.com/content/79/16/1671.abstract AB背景:Neuromyelitis视(动)是一种严重的中枢神半岛投注体育官网经系统炎性脱髓鞘疾病的致病作用anti-aquaporin-4 (AQP4)抗体。尽管AQP4表达在人类大脑皮层,最近的组织学研究没有找到任何证据证明皮质髓鞘脱失的动。目的:评估、体内病灶的发生和扩散皮质病理在动。方法:我们研究了30个病人动,30例复发缓和多发性硬化患者(名RRMS)和30名正常对照组(NC)。名RRMS和数控时代——动校正的准确性。皮质病变的存在(CLs)评估双反转恢复序列和皮质厚度(车车)的应用3日Freesurfer体积快速场回波t1影像。结果:没有观察到在数控或动,CL 83 CLs被确定在20/30(66.7%)名RRMS患者。虽然在全球动没有不同于数控车车,轻度稀释某些皮质(中央后(p = 0.018),中央前(p = 0.009)和距状(p = 0.015)脑回)和丘脑(p = 0.036)。全球和区域皮质厚度显著减少名RRMS相比,动校正和数控。 Discussion: Our in vivo data further suggest that the immune-mediated pathologic process occurring in NMO spares most of the cortex. NMO differs from multiple sclerosis, where CLs and atrophy are frequently found, even in early disease phases. Thus, MRI analysis of the cortex may be a potential diagnostic tool, especially in ambiguous cases. AQPR=aquaporin-4; CL=cortical lesion; CTh=cortical thickness; DIR=double inversion recovery; ETL=echo train length; FLAIR=fluid-attenuated inversion recovery; FOV=field of view; GM=gray matter; MS=multiple sclerosis; NC=normal control; NMO=neuromyelitis optica; RRMS=relapsing-remitting multiple sclerosis; TE=echo time; TI=inversion time; TR=repetition time; WM=white matter.