PT -期刊文章盟诺阿花茎甘蓝AU - Mi太阳哦,非盟-爱丽丝Favaretto盟弗朗西斯卡里纳尔蒂盟瓦伦蒂娜Poretto AU -萨拉塞盟Byung-Chul李盟- Yu庆浩盟-马Hyeo-Il盟Paola Perini盟——保罗·盖洛TI -没有皮质病变的MRI证据- 10.1212 / WNL视neuromyelitis援助。0 b013e31826e9a96 DP - 2012年10月16日TA -神半岛投注体育官网经病学第六PG - 1671 - 1676 - 79 IP - 16 4099 - //www.ebmtp.com/content/79/16/1671.short 4100 - //www.ebmtp.com/content/79/16/1671.full所以Neurology2012 10月16日;视79 AB -背景:Neuromyelitis(动)是一种严重的中枢神经系统炎性脱髓鞘疾病的致病作用anti-aquaporin-4 (AQP4)抗体。尽管AQP4表达在人类大脑皮层,最近的组织学研究没有找到任何证据证明皮质髓鞘脱失的动。目的:评估、体内病灶的发生和扩散皮质病理在动。方法:我们研究了30个病人动,30例复发缓和多发性硬化患者(名RRMS)和30名正常对照组(NC)。名RRMS和数控时代——动校正的准确性。皮质病变的存在(CLs)评估双反转恢复序列和皮质厚度(车车)的应用3日Freesurfer体积快速场回波t1影像。结果:没有观察到在数控或动,CL 83 CLs被确定在20/30(66.7%)名RRMS患者。虽然在全球动没有不同于数控车车,轻度稀释某些皮质(中央后(p = 0.018),中央前(p = 0.009)和距状(p = 0.015)脑回)和丘脑(p = 0.036)。全球和区域皮质厚度显著减少名RRMS相比,动校正和数控。 Discussion: Our in vivo data further suggest that the immune-mediated pathologic process occurring in NMO spares most of the cortex. NMO differs from multiple sclerosis, where CLs and atrophy are frequently found, even in early disease phases. Thus, MRI analysis of the cortex may be a potential diagnostic tool, especially in ambiguous cases. AQPR=aquaporin-4; CL=cortical lesion; CTh=cortical thickness; DIR=double inversion recovery; ETL=echo train length; FLAIR=fluid-attenuated inversion recovery; FOV=field of view; GM=gray matter; MS=multiple sclerosis; NC=normal control; NMO=neuromyelitis optica; RRMS=relapsing-remitting multiple sclerosis; TE=echo time; TI=inversion time; TR=repetition time; WM=white matter.