@article {Calabrese1671作者= {Massimiliano花茎甘蓝和Mi太阳哦和爱丽丝Favaretto弗朗西斯卡里纳尔蒂和瓦伦蒂娜Poretto和莎拉塞Byung-Chul李和庆浩Yu和马Hyeo-Il Paola Perini和保罗·盖洛},title ={没有皮质病变的MRI证据neuromyelitis视},体积={79}={16},页面= {1671 - 1676}= {2012},doi = {10.1212 / WNL。出版商0 b013e31826e9a96} = {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景:Neuromyelitis视(动)是一种严重的中枢神经系统炎性脱髓鞘半岛投注体育官网疾病的致病作用anti-aquaporin-4 (AQP4)抗体。尽管AQP4表达在人类大脑皮层,最近的组织学研究没有找到任何证据证明皮质髓鞘脱失的动。目的:评估、体内病灶的发生和扩散皮质病理在动。方法:我们研究了30个病人动,30例复发缓和多发性硬化患者(名RRMS)和30名正常对照组(NC)。名RRMS和数控时代——动校正的准确性。皮质病变的存在(CLs)评估双反转恢复序列和皮质厚度(车车)的应用3日Freesurfer体积快速场回波t1影像。结果:没有观察到在数控或动,CL 83 CLs被确定在20/30(66.7 \ %)名RRMS患者。虽然在全球动没有不同于数控车车,轻度稀释某些皮质(中央后(p = 0.018),中央前(p = 0.009)和距状(p = 0.015)脑回)和丘脑(p = 0.036)。全球和区域皮质厚度显著减少名RRMS相比,动校正和数控。讨论:我们的体内数据进一步表明,免疫介导的病理过程发生在动备件大部分大脑皮层。 NMO differs from multiple sclerosis, where CLs and atrophy are frequently found, even in early disease phases. Thus, MRI analysis of the cortex may be a potential diagnostic tool, especially in ambiguous cases. AQPR=aquaporin-4; CL=cortical lesion; CTh=cortical thickness; DIR=double inversion recovery; ETL=echo train length; FLAIR=fluid-attenuated inversion recovery; FOV=field of view; GM=gray matter; MS=multiple sclerosis; NC=normal control; NMO=neuromyelitis optica; RRMS=relapsing-remitting multiple sclerosis; TE=echo time; TI=inversion time; TR=repetition time; WM=white matter.}, issn = {0028-3878}, URL = {//www.ebmtp.com/content/79/16/1671}, eprint = {//www.ebmtp.com/content/79/16/1671.full.pdf}, journal = {Neurology} }