TY - T1的内侧颞叶萎缩在MRI在正常老化和轻度阿尔茨海默病JF -神经学乔-神经病学SP - 786 LP - 794 - 10.1212 / WNL.49.3.786六世- 49 - 3 AU 半岛投注体育官网-克利福德·r·杰克,小非盟-罗纳德·c·彼得森盟曰程徐盟——斯蒂芬·c·华林盟——彼得·c·奥布莱恩AU -埃里克·g·Tangalos盟格伦·e·史密斯AU - Robert j . Ivnik盟埃姆雷Kokmen Y1 - 1997/09/01 UR - //www.ebmtp.com/content/49/3/786.abstract N2 -核磁共振成像(MRI)的体积测量的内侧颞叶(MTL)结构可以区分正常老年对照组和阿尔茨海默病(AD)患者中度到先进的严重性。在临床效用方面,然而,一个更重要的问题的能力技术来区分正常老年对照组和AD患者非常的温和形式的疾病。我们进行mri体积测量海马,海马旁回,杏仁核在126年认知正常的老年人对照组和94年患者可能的广告。广告的诊断是根据研究所/ ADRDA标准,和疾病严重程度分类,临床痴呆评定(CDR)的分数。CDR 0.5患者分为轻度,CDR 1温和,温和的疾病严重程度和CDR 2。每个结构的卷在对照组下降,随着年龄增长,也因此在平行为男性和女性。每个测量的体积MTL结构也拒绝AD患者随着年龄的增长。The volume of each MTL structure was significantly smaller in AD patients than control subjects (p < 0.001). Of the several MTL measures, the total hippocampal volumetric measurements were best at discriminating control subjects from AD patients. The mean hippocampal volumes for AD patients relative to control subjects by severity of disease were as follows: very mild AD (CDR 0.5) -1.75 SD below the control mean, mild AD (CDR 1) -1.99 SD, and moderate AD (CDR 2) -2.22 SD. Age- and gender-adjusted, normalized MRI-based hippocampal volumetric measurements provide a sensitive marker of the MTL neuroanatomic degeneration in AD early in the disease process. ER -