@article {Kamal10.1212 / WNL。0000000000207514,作者= {Farooq Kamal卡桑德拉莫里森和Josefina Maranzano Yashar Zeighami和Mahsa Dadar}, title =轨迹{白质高密度进步和稳定的轻度认知障碍患者},elocation-id = {10.1212 / WNL。={2023}0000000000207514},年,doi = {10.1212 / WNL。出版商0000000000207514}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景和目的:脑白质hyperintensities是大脑病理变化与年龄的增加和半岛投注体育官网认知能力下降有关。然而,负担协会白质高密度与淀粉样积极性和转换在轻度认知障碍(MCI)患者痴呆尚不清楚。当前研究的目的是为了扩展这项研究通过检查是否负担随着时间变化白质高密度不同amyloid-negative (Aβ)和amyloid-positive (Aβ+)患有轻度认知障碍的人保持稳定或转换为痴呆。检查这个问题,我们负担区域白质高密度四组相比:淀粉样蛋白阳性(Aβ+)不寻常,淀粉样蛋白阴性(Aβ{\ textendash})不寻常,淀粉样蛋白阳性(Aβ+)稳定,淀粉样蛋白- (Aβ{\ textendash})稳定。方法:参与者的MCI {\ textquoteright}年代老年痴呆症神经影像倡议包括如果他们APOEɛ4地位和淀粉样蛋白措施可用来确定(即淀粉样状态。,淀粉样蛋白阳性,或淀粉样蛋白-)。参与者与基线MCI诊断,APOEɛ4信息和淀粉样蛋白措施包括在内。5.7的平均随访时间点每个参与者都包括在内,共有5054随访时间点最大后续13年时间。负担总差异和区域白质高密度使用线性mixed-effects模型检查。结果:共有820名参与者(55 - 90岁)被包括在研究({\党卫军}+不寻常,n = 239;{\党卫军}{\ textendash}不寻常,n = 22; A{\ss}+ Stable, n= 343; A{\ss}{\textendash} Stable, n= 216). People who were A{\ss}{\textendash} stable exhibited reduced baseline white matter hyperintensities compared to A{\ss}+ progressors and A{\ss}+ stable at all regions of interest (β belongs to [.20 {\textendash}.33], CI belongs to [.03 {\textendash}.49], p\<.02), except Deep white matter hyperintensities. When examining longitudinal results, compared to A{\ss}{\textendash} stable, all groups had steeper accumulation in white matter hyperintensity burden with A{\ss}+ progressors (β belongs to [-.03{\textendash}.06], CI belongs to [-.05{\textendash}.09], p\<.01) having the largest increase (i.e., largest increase in white matter hyperintensity accumulation over time).Discussion: These results indicate that white matter hyperintensity accumulation contributes to conversion to dementia in older adults with mild cognitive impairment who are amyloid-positive and negative people.}, issn = {0028-3878}, URL = {//www.ebmtp.com/content/early/2023/07/05/WNL.0000000000207514}, eprint = {//www.ebmtp.com/content/early/2023/07/05/WNL.0000000000207514.full.pdf}, journal = {Neurology} }