@article {Wue189作者= {Yu-Chien吴不干了温家宝和土卫五。祖卡罗尔和何晶杨和杰西卡·m·吉尔Sujuan高和凯瑟琳·a·莱恩和蒂莫西·b·迈耶和拉里·d·Riggen雅罗斯瓦夫Harezlak和克里斯托弗·c·吉萨和约书亚高盛和凯文·m·Guskiewicz和杰森·p·Mihalik和斯蒂芬·m·LaConte斯蒂芬·m·杜马和Steven p . Broglio安德鲁j . Saykin沃克和托马斯·麦卡利斯特和迈克尔·a·麦克雷博士},title ={纵向之间的关联血液生物标志物和白质MRI在体育运动相关的脑震荡},体积={101}={2},页面= {e189——e201} = {2023}, doi = {10.1212 / WNL。出版商0000000000207389}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景和目标研究纵向blood-based神经生物标志物之间的关联(包括总τ、光半岛投注体育官网神经丝(NfL)、胶质原纤维酸性蛋白(GFAP)和泛素c端hydrolase-L1)和白质神经影像生物标志物在大学生运动员与体育运动相关的脑震荡(SRC) 24小时postinjury 1星期后返回。方法分析临床和影像数据有脑震荡的大学生运动员脑震荡的评估,研究和教育(保健)财团。照顾参与者完成了当天的临床评估,血液吸引,和扩散张量成像(DTI)在三个时间点:24 {\ textendash} 48小时受伤后变得无症状,和7天后返回。DTI概率tractography执行每个参与者在每个时间点呈现27 participant-specific主要白质束。这些大片的微观结构组织4 DTI指标的特点。Mixed-effects模型与随机拦截应用于测试白质显微结构的异常是否与blood-based相关生物标记物在同一时间点。一个交互模型被用来测试是否协会在时间点不同。滞后模型用来测试是否早期blood-based生物标志物预测后显微结构的变化。77大学生运动员的数据结果包括在以下分析。4 blood-based中生物标志物,总τ有重大关联的DTI指标在三个时间点。特别是,τ级与径向扩散系数高(RD)对皮质脊髓束(β= 0.25,= 0.07,pFDR-adjusted = 0.016)和优越的丘脑的辐射(β= 0.21,= 0.07,pFDR-adjusted = 0.042)。NfL和GFAP和DTI度量时间关联。 NfL showed significant associations only at the asymptomatic time point (|β|s \> 0.12, SEs \<0.09, psFDR-adjusted \< 0.05) and GFAP showed a significant association only at 7 days after return to play (βs \> 0.14, SEs \<0.06, psFDR-adjusted \< 0.05). The p values for the associations of early tau and later RD were not significant after multiple comparison adjustment, but were less than 0.1 in 7 white matter tracts.Discussion This prospective study using data from the CARE Consortium demonstrated that in the early phase of SRC, white matter microstructural integrity detected by DTI neuroimaging was associated with elevated levels of blood-based biomarkers of traumatic brain injury. Total tau in the blood showed the strongest association with white matter microstructural changes.AD=axial diffusivity; CARE=Concussion Assessment, Research, and Education Consortium; CoV=coefficient of variance; DoD=Department of Defense; DTI=diffusion tensor imaging; FA=fractional anisotropy; FDR=false discovery rate; GFAP=glial fibrillary acidic protein; MD=mean diffusivity; mTBI=mild TBI; NCAA=National Collegiate Athletic Association; NfL=neurofilament light; RD=radial diffusivity; SRC=sport-related concussion; TBI=traumatic brain injury; TOI=tract of interest; UCH-L1=ubiquitin C-terminal hydrolase-L1; UCLA=University of California Los Angeles; UNC=University of North Carolina; VT=Virginia Tech}, issn = {0028-3878}, URL = {//www.ebmtp.com/content/101/2/e189}, eprint = {//www.ebmtp.com/content/101/2/e189.full.pdf}, journal = {Neurology} }