RT期刊文章SR电子T1临床神经生理和病理功能患者的早期发病标明辐射神经病摩根富林明神经学神经学乔FD Lippincott Williams &威尔金斯10.1212 SP / WNL。半岛投注体育官网0000000000207545 10.1212 / WNL。0000000000207545 A1迈克尔Skolka A1日常用品的雪莱A1马库斯诉平托A1 Divyanshu Dubey A1达Oishi A1俊h .嗯A1阿什利Santilli A1 Nathan P员工A1罗伯特转轮A1 P·詹姆斯·b·戴克A1嘉莉伊丽莎白·罗伯逊A1克里斯托弗·j·克莱因年2023 UL //www.ebmtp.com/content/early/2023/07/03/WNL.0000000000207545.abstract AB目的:研究早发性辐射诱导神经病变检查神经,steroid-半岛投注体育官网response,可用神经活检。方法:患者的辐射诱导神经病变内资料综述了辐射从1月1日,1999 - 2022年8月31日。病人必须electrodiagnostically证实神经病变局部内或远端辐射领域。综述了神经,神经活检。结果:28例(16 12男性和女性,平均年龄63.8岁)被确定。平均辐射剂量是4659 cgy(范围1000 - 7208)。肿瘤浸润在MRI和PET没有被观察到。辐射后发作平均2个月(范围0 - 5)。本地化包括臂(n = 4) plexopathies、腰骶的(n = 12) plexopathies,神经根病(n = 10),和单神经病(n = 2)。神经性疼痛(n = 25)和缺点(n = 25)是典型的。 The clinical courses were subacute monophasic (n=14), chronic progressive (n=8) or static (n=1), and 5 were without follow-up. Nerve biopsies (n=8) showed an inflammatory ischemic process with perivascular inflammatory infiltrates (n=7) or microvasculitis (n=2). Nine patients, 7 with monophasic courses, received steroid burst therapy with symptom improvement in 8. No patients recovered entirely back to baseline.Discussion: In contrast to chronic radiation induced neuropathy early-onset patients most commonly have painful, monophasic courses with residual deficits, possibly steroid responsive. An ischemic inflammatory pathogenesis is suggested.