PT -期刊文章盟迈克尔Skolka AU -日常用品的雪莱AU -马库斯诉平托盟Divyanshu Dubey盟俊h .嗯- Oishi达盟盟-阿什利Santilli盟Nathan P员工非盟——罗伯特转轮盟——P·詹姆斯·b·戴克AU -凯莉伊丽莎白·罗伯逊盟克里斯托弗·j·克莱因TI -临床神经生理和病理功能患者的早期发病标明辐射- 10.1212 / WNL神经病援助。0000000000207545 DP - 2023 7月03 TA -神经病半岛投注体育官网学PG - 10.1212 / WNL。0000000000207545 4099 - http://n.半岛投注体育官网neurology.org/content/early/2023/07/03/WNL.0000000000207545.short 4100 - //www.ebmtp.com/content/early/2023/07/03/WNL.0000000000207545.full AB -目的:研究早发性辐射诱导神经病变检查神经,steroid-response,可用神经活检。方法:患者的辐射诱导神经病变内资料综述了辐射从1月1日,1999 - 2022年8月31日。病人必须electrodiagnostically证实神经病变局部内或远端辐射领域。综述了神经,神经活检。结果:28例(16 12男性和女性,平均年龄63.8岁)被确定。平均辐射剂量是4659 cgy(范围1000 - 7208)。肿瘤浸润在MRI和PET没有被观察到。辐射后发作平均2个月(范围0 - 5)。本地化包括臂(n = 4) plexopathies、腰骶的(n = 12) plexopathies,神经根病(n = 10),和单神经病(n = 2)。神经性疼痛(n = 25)和缺点(n = 25)是典型的。 The clinical courses were subacute monophasic (n=14), chronic progressive (n=8) or static (n=1), and 5 were without follow-up. Nerve biopsies (n=8) showed an inflammatory ischemic process with perivascular inflammatory infiltrates (n=7) or microvasculitis (n=2). Nine patients, 7 with monophasic courses, received steroid burst therapy with symptom improvement in 8. No patients recovered entirely back to baseline.Discussion: In contrast to chronic radiation induced neuropathy early-onset patients most commonly have painful, monophasic courses with residual deficits, possibly steroid responsive. An ischemic inflammatory pathogenesis is suggested.