@article {Skolka10.1212 / WNL。0000000000207545,作者={迈克尔Skolka雪莱日常用品和马库斯诉平托Dubey Divyanshu和达Oishi h .嗯,俊和阿什利Santilli和Nathan P员工和罗伯特·转轮和P·詹姆斯·b·戴克和凯莉·伊丽莎白·罗伯逊和克里斯托弗·j·克莱因},title ={患者临床、神经生理和病理功能早发性标明辐射神经病},elocation-id = {10.1212 / WNL。={2023}0000000000207545},年,doi = {10.1212 / WNL。出版商0000000000207545}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:探讨早发性辐射诱导神经病变检查神经,steroid-response,神半岛投注体育官网经活检和可用。方法:患者的辐射诱导神经病变内资料综述了辐射从1月1日,1999 - 2022年8月31日。病人必须electrodiagnostically证实神经病变局部内或远端辐射领域。综述了神经,神经活检。结果:28例(16 12男性和女性,平均年龄63.8岁)被确定。平均辐射剂量是4659 cgy(范围1000 - 7208)。肿瘤浸润在MRI和PET没有被观察到。辐射后发作平均2个月(范围0 - 5)。本地化包括臂(n = 4) plexopathies、腰骶的(n = 12) plexopathies,神经根病(n = 10),和单神经病(n = 2)。 Neuropathic pain (n=25) and weakness (n=25) were typical. The clinical courses were subacute monophasic (n=14), chronic progressive (n=8) or static (n=1), and 5 were without follow-up. Nerve biopsies (n=8) showed an inflammatory ischemic process with perivascular inflammatory infiltrates (n=7) or microvasculitis (n=2). Nine patients, 7 with monophasic courses, received steroid burst therapy with symptom improvement in 8. No patients recovered entirely back to baseline.Discussion: In contrast to chronic radiation induced neuropathy early-onset patients most commonly have painful, monophasic courses with residual deficits, possibly steroid responsive. An ischemic inflammatory pathogenesis is suggested.}, issn = {0028-3878}, URL = {//www.ebmtp.com/content/early/2023/07/03/WNL.0000000000207545}, eprint = {//www.ebmtp.com/content/early/2023/07/03/WNL.0000000000207545.full.pdf}, journal = {Neurology} }