@article {Geraudie10.1212 / WNL。0000000000207516,作者={含有杏仁的Geraudie和彼得S Pressman杰雷米Pariente和卡莉Millanski埃莉诺·r .朋友和Buddhika m . Ratnasiri Giovanni Battistella和玛丽亚·路易莎铜质把手扎卡里·a·米勒和布鲁斯·l·米勒和弗吉尼亚Sturm凯瑟琳·兰金P和玛丽亚·路易莎Gorno-Tempini马克西姆Montembeault}, title ={表达韵律焦前颞神经退化患者},elocation-id = {10.1212 / WNL。={2023}0000000000207516},年,doi = {10.1212 / WNL。出版商0000000000207516}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={简介:进步焦前颞叶(ATL)神经退化已被历史上称为语义痴呆。半岛投注体育官网最近,语义变体原发性进行性失语(svPPA)和语义行为变异额颞叶痴呆(sbvFTD)与主要向左或向右颞叶退化,分别。然而,临床准确诊断工具sbvFTD仍然缺乏。表达韵律指的是调制的音调,响度,速度和质量的声音用来传达情感和语言信息,与两国但right-predominant额颞叶功能。表达韵律的变化可以被探测到半自动化方法和可能是一个有用的诊断sbvFTD socio-emotional功能状态的标志。方法:参与者接受了全面的神经心理学和语言评价和3 t MRI在加州大学旧金山分校。野餐的每个参与者提供了一个口头描述场景西部失语电池。基本频率(f0)范围内,音高的变化的声学测量,提取每个参与者。我们比较f0范围之间的组织和研究协会的informant-rated测量移情,面部情绪标签的任务,灰质卷使用分布形态测量学。结果:28 svPPA患者,与sbvFTD 18岁,18名健康对照组(HC)包括在内。 f0 range was significantly different across groups: sbvFTD patients showed reduced f0 in comparison to both patients with svPPA (mean difference of -1.4{\textpm}2.4 semitones; 95\% CI [-2.4, -0.4]; p \< .005), and HC (mean difference of -1.9{\textpm}3.0 semitones; 95\% CI [-3.0, -0.7]; p \< .001). f0 range was significantly positively correlated with informant-rated empathy (r = .355; p <= .05), but not facial emotion labelling. Finally, the f0 range was significantly correlated with gray matter volume in the right superior temporal gyrus, encompassing anterior and posterior portions (p \< .05 FWE cluster corrected).Conclusion: Expressive prosody may be a useful clinical marker of sbvFTD. Reduced empathy is a core symptom in sbvFTD; the present results extend this to prosody, a core component of social interaction, at the intersection of speech and emotion. They also inform the long-standing debate on the lateralization of expressive prosody in the brain, highlighting the critical role of the right superior temporal lobe.}, issn = {0028-3878}, URL = {//www.ebmtp.com/content/early/2023/07/03/WNL.0000000000207516}, eprint = {//www.ebmtp.com/content/early/2023/07/03/WNL.0000000000207516.full.pdf}, journal = {Neurology} }