% 0期刊文章%一个阿米莉亚·j·希克斯%本杰明·辛克莱%桑迪·R·舒尔茨%一个威廉Pham % %丽莎·c·希尔伯特Daniel l . Schwartz %一个珍妮·l·克里斯托弗·c·罗% Ponsford %孟法律%革顺猎犬% T协会扩大血管周的空间与脑损伤、脑年龄和临床结果在慢性创伤性脑损伤% D R 10.1212 / WNL 2023%。0000000000207370 % J半岛投注体育官网神经病学% P e63-e73 % V 101% N 1% X背景和目标扩大血管周的空间(ePVS)已被确定为一个关键的签名glymphatic在神经系统功能障碍的条件。的发病率和临床意义ePVS创伤性脑损伤(TBI)后还不理解。我们调查是否患有慢性严重创伤性脑损伤的负担增加ePVS以及是否ePVS负担调制的存在局部病变,大脑年龄老,睡眠质量差。我们检查是否增加负担ePVS与贫穷有关认知和情感的结果。方法使用横断面设计中,参与者用一个严重慢性创伤性脑损伤(持续≥10年前)招募了住院康复计划。控制从社区招募参与者。参与者进行了脑磁共振3 t、神经心理评估和临床评价。ePVS负担在白质量化使用自动分割。ePVS的数量之间的关系,团体会员,局部病变,大脑年龄,现在的睡眠质量,结果是用负二项和线性回归建模。结果这个研究包括了100名参与者和创伤性脑损伤(男性70%;平均年龄= 56.8年)和75年控制参与者(男性54.3%; mean age = 59.8 years). The TBI group had a significantly greater burden of ePVS (prevalence ratio rate [PRR] = 1.29, p = 0.013, 95% CI 1.05–1.57). The presence of bilateral lesions was associated with greater ePVS burden (PRR = 1.41, p = 0.021, 95% CI 1.05–1.90). There was no association between ePVS burden, sleep quality (PRR = 1.01, p = 0.491, 95% CI 0.98–1.048), and sleep duration (PRR = 1.03, p = 0.556, 95% CI 0.92–1.16). ePVS was associated with verbal memory (β = −0.42, p = 0.006, 95% CI −0.72 to −0.12), but not with other cognitive domains. The burden of ePVS was not associated with emotional distress (β = −0.70, p = 0.461, 95% CI −2.57 to 1.17) or brain age (PRR = 1.00, p = 0.665, 95% CI 0.99–1.02).Discussion TBI is associated with a greater burden of ePVS, especially when there have been bilateral brain lesions. ePVS was associated with reduced verbal memory performance. ePVS may indicate ongoing impairments in glymphatic system function in the chronic postinjury period.AQP4=aquaporin-4; ePVS=enlarged PVS; FLAIR=fluid-attenuated inversion recovery; GCS=Glasgow coma scale; GOSE=Glasgow Outcome Scale–Extended; MAPS=Multimodal Autoidentification of Perivascular Spaces; PRR=prevalence rate ratio; PSQI=Pittsburgh Sleep Quality Index; PTA=posttraumatic amnesia; PVS=perivascular space; TBI=traumatic brain injury; WTAR=Wechsler Test of Adult Reading %U //www.ebmtp.com/content/neurology/101/1/e63.full.pdf