@article {Liu10.1212 / WNL。0000000000207484,作者={轨迹刘Shilan关丽珍和凌,赵开元和延安王宇通张和Ziwen王先生和李以下太阳和胡},title ={评价聚类的方法来定义不同的子组的偏头痛患者选择电针刺激治疗},elocation-id = {10.1212 / WNL。={2023}0000000000207484},年,doi = {10.1212 / WNL。出版商0000000000207484}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景和目标:提出一种聚类方法确定偏头痛子组和测试的临床实用性的方法通过提供预后半岛投注体育官网信息电针刺激治疗选择。方法:参与者与先兆型偏头痛(MWoA)被要求完成每日头痛日记,自我评定的抑郁和焦虑,生活质量调查问卷。全脑功能连接性(FCs)在静息状态功能磁共振成像评估。通过整合临床测量和功能磁共振成像数据,偏最小二乘的相关性和层次聚类分析被用来与MWoA集群参与者。多元模式分析应用来验证该子群的策略。一些参与者有8周电针刺激治疗,和响应率不同MWoA子组之间的比较。结果:在研究1中,97名参与者(28.2 {\ textpm} 1.0岁,70名女性)与MWoA和77名健康对照组(高碳钢)(26.8 {\ textpm} 0.1岁,61名女性)为(数据集1),和两个MWoA子组被定义。群1中的参与者有显著降低头痛频率(次/月的4.4 {\ textpm} 1.1)和显著提高抑郁症的评价(抑郁得分49.5 {\ textpm} 2.3)与子群2中的参与者(次/月的7.0 {\ textpm} 0.6和抑郁得分43.4 {\ textpm} 1.2)。FCs的差异主要与杏仁核、丘脑、海马、海马旁区域。 In study 2, 33 participants with MWoA (age of 30.9 {\textpm} 2.0 years, 28 females) and 23 HCs (age of 29.8 {\textpm} 1.1 years, 13 females) were enrolled as an independent dataset (dataset 2). The classification analysis validated the effectiveness of the two-cluster solution of participants with MWoA in datasets 1 and 2. In study 3, 58 participants with MWoA were willing to receive electroacupuncture treatment and were assigned to different subgroups. Participants in different subgroups exhibited different response rates (p = 0.03, OR CI = 0.086-0.93) to electroacupuncture treatment (18\% and 44\% for subgroups 1 and 2, respectively).Discussion: Our study proposed a novel clustering approach to define distinct MWoA subgroups, which could be useful for refining the diagnosis of participants with MWoA and guiding individualized strategies for pain prophylaxis and analgesia.}, issn = {0028-3878}, URL = {//www.ebmtp.com/content/early/2023/06/22/WNL.0000000000207484}, eprint = {//www.ebmtp.com/content/early/2023/06/22/WNL.0000000000207484.full.pdf}, journal = {Neurology} }