@article {Bjornevik10.1212 / WNL。0000000000207485,作者= {Kjetil Bjornevik和玛丽安娜Cortese和杰里米·D Furtado和塞布丽娜Paganoni迈克尔·a·史瓦西和绩效大肠Cudkowicz Alberto Ascherio博士},title ={协会的多不饱和脂肪酸和ALS患者的临床进展:事后的分析使审判},elocation-id = {10.1212 / WNL。={2023}0000000000207485},年,doi = {10.1212 / WNL。出版商0000000000207485}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景和目的:多不饱和脂肪酸(欧米伽)神经保护和抗炎作用可能是有益的肌萎缩性脊髓半岛投注体育官网侧索硬化症(ALS)。更高的膳食摄入量和等离子体水平的欧米伽,尤其是亚麻酸(ALA),已与大型流行病学队列研究肌萎缩性侧索硬化症的风险较低,但数据ALS患者的疾病进展是稀疏的。我们检查是否等离子体水平的阿拉巴马州和其他欧导致预测ALS患者的生存时间和功能下降。方法:我们进行了一项研究的参与者赋予人血浆样品收集临床试验随机化的时候,可用于脂肪酸分析。血浆脂肪酸使用气相色谱法测定。我们使用Cox比例风险模型和线性回归来评估个体协会脂肪酸与死亡风险和joint-rank测试成绩的功能下降和生存。结果:在449名参与者脂肪酸进行了分析。这些参与者的平均年龄(SD)在基线是57.5(10.7)和293年(65.3 \ %)是男性;126(28.1 \ %)随访中丧生。 Higher ALA levels were associated with lower risk of death (age and sex-adjusted hazard ratio [HR] comparing highest vs. lowest quartile: 0.50, 95\% CI: 0.29 to 0.86, p-trend: 0.041) and higher joint-rank test score (difference in score according to 1 SD increase: 10.7, 95\% CI: 0.2 to 21.1, p = 0.045), consistent with a slower functional decline. The estimates remained similar in analyses adjusted for BMI, race/ethnicity, symptom duration, site of onset, riluzole use, family history of ALS, predicted upright slow vital capacity, and treatment group. Higher levels of the n-3 fatty acid eicosapentaenoic acid (EPA) and the n-6 fatty acid linoleic acid (LA) were associated with a lower risk of death during follow-up.Conclusions: Higher levels of ALA were associated with longer survival and slower functional decline in ALS patients. These results suggest that ALA may have a favorable effect on disease progression in ALS patients.}, issn = {0028-3878}, URL = {//www.ebmtp.com/content/early/2023/06/21/WNL.0000000000207485}, eprint = {//www.ebmtp.com/content/early/2023/06/21/WNL.0000000000207485.full.pdf}, journal = {Neurology} }