TY -的T1神经功能紊乱的经济成本:系统回顾JF -神经学乔-神经- 10.1212 / WNL。半岛投注体育官网0000000000207388 SP - 10.1212 / WNL。0000000000207388盟盟Brian O’mahony -格伦·尼尔森盟Sallie巴克辛德尔AU - Mark J爱德华兹盟达Yogarajah Y1 - 2023/06/20 UR - //www.ebmtp.com/content/early/2023/06/20/WNL半岛投注体育官网.0000000000207388.abstract N2 - IntroductionFunctional神经障碍(曾经)代表真正的无意识的神经系统症状和体征包括癫痫、弱点和感觉障碍特点临床特征,并代表自愿控制和感知的问题尽管正常的神经系统的基本结构。曾经的历史观点的诊断排除可能导致不必要的医疗资源利用率,和高的直接和间接经济损失。系统回顾了使用棱镜指南,以评估这些经济成本,并评估对任何具有成本效益的治疗。MethodsWe搜索电子数据库(Pubmed、PsycInfo Medline和EMBASE,和国家卫生服务经济评估数据库约克大学的)原始,主要研究出版物《盗梦空间》之间的数据库和2022年4月8日。hand-search会议摘要也进行了。关键搜索词包括“功能神经障碍”、“转换障碍”和“功能性痉挛”。评论、病例报告、病例分析和定性研究被排除在外。我们进行了描述和定性专题分析结果studiesResultsThe搜索导致共有3244项研究。16个研究包括筛选后,排除重复。 These included: cost-of-illness (COI) studies which were conducted alongside cohort studies without intervention, and included a comparator group, e.g. another neurological disorder (n=4); COI studies which were conducted alongside cohort studies without intervention, and which did not include a comparator group (n=4); economic Evaluations (EE) of interventions which were either pre-post cohort studies (n=6) or randomized controlled trials (n=2). Of these, five studies assessed active interventions, and three studies assessed costs before and after a definitive diagnosis of FND.Studies showed an excess annual cost associated with FND (range $4,964 to $86,722 2021 USD), which consisted of both direct, but also large indirect costs. Studies showed promise that interventions, including provision of a definitive diagnosis, could reduce this cost (range 9% to 90.7%). No cost-effective treatments were identified. Study comparison was limited by study design and location heterogeneityConclusionFND is associated with significant use of healthcare resources, resulting in economic costs to both the patient and the tax-payer, as well as intangible losses. Interventions, including accurate diagnosis, appear to offer an avenue towards reducing these costs. ER -