RT期刊文章SR电子T1的时机和预测T2-Lesion决议Myelin-Oligodendrocyte-Glycoprotein-Antibody-Associated疾病患者摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯10.1212 SP / WNL。半岛投注体育官网0000000000207478 10.1212 / WNL。0000000000207478 A1劳拉Cacciaguerra A1 Vyanka Redenbaugh A1约翰J陈A1皮尔斯莫里斯A1伊利亚Sechi A1斯蒂芬妮·B Syc-Mazurek A1。塞巴斯蒂安Lopez-Chiriboga A1 Jan-Mendelt Tillema A1玛丽亚·a·罗卡A1马西莫菲利皮主持A1肖恩·J Pittock A1 Eoin P弗拉纳根年2023 UL //www.ebmtp.com/content/early/2023/半岛投注体育官网06/16/WNL.0000000000207478.abstract AB的目标。确定的时间和预测T2-lesion myelin-oligodendrocyte-glycoprotein-antibody-associated疾病(MOGAD) .Methods决议。回顾性观察研究使用标准数据的入选标准:MOGAD诊断> 2 MRI是12个月,大脑和脊髓T2-lesion > 1。中位数(四分位范围(差)的MRI在疾病发作(82%)的平均是:大脑,5 (2 - 8);脊柱,4 (2 - 8)。预测T2-lesion决议评估随着年龄的增长,sex-adjusted广义估计方程和分层T2-lesion大小(小< 1厘米;大型.Results≥1厘米)。我们研究了583 t2损伤(大脑中,512 (88%); spinal cord, 71[12%]) from 55 patients. At last MRI (median follow-up 54 months[IQR, 7-74]), 455 T2-lesions (78%) resolved. The median (IQR) time to resolution was 3 months (1.4-7.0). Small T2-lesions resolved more frequently and faster than large T2-lesions. Acute T1-hypointesity decreased the likelihood (odds ratio[95% confidence interval]) of T2-lesion resolution independent of size (small: 0.23[0.09, 0.60], p=0.002; large: 0.30[0.16, 0.55], p<0.001) while acute steroids favored resolution of large T2-lesions (1.75[1.01, 3.03], p=0.046). Notably, 32/55 (58%) T2-lesions resolved without treatment.Discussion. The high frequency of spontaneous T2-lesion resolution suggests this represents MOGAD’s natural history. The speed of T2-lesion resolution and influence of size, corticosteroids and T1-hypointensity on this phenomenon gives insight into MOGAD pathogenesis.