@article {Cacciaguerra10.1212 / WNL。0000000000207478,作者={劳拉Cacciaguerra Vyanka Redenbaugh和约翰J陈和皮尔斯莫里斯和伊利亚Sechi斯蒂芬妮·B Syc-Mazurek和a·塞巴斯蒂安Lopez-Chiriboga Jan-Mendelt Tillema和玛丽亚·a·罗卡马西莫菲利皮主持和肖恩·J Pittock Eoin P弗拉纳根},title ={时机和预测T2-Lesion决议Myelin-Oligodendrocyte-Glycoprotein-Antibody-Associated疾病患者},elocation-id = {10.1212 / WNL。={2023}0000000000207478},年,doi = {10.1212 / WNL。出版商0000000000207478}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目标。半岛投注体育官网确定的时间和预测T2-lesion myelin-oligodendrocyte-glycoprotein-antibody-associated疾病(MOGAD) .Methods决议。本回顾性观察研究使用标准治疗数据的入选标准:MOGAD诊断\ > 2 MRI {\ textquoteright} s 12个月,脊髓和大脑\ > 1 / T2-lesion。中位数(四分位范围(差)的MRI {\ textquoteright}年代发病(82 \ %)平均是:大脑,5 (2 - 8);脊柱,4 (2 - 8)。预测T2-lesion决议评估随着年龄的增长,sex-adjusted广义估计方程和分层T2-lesion大小(小\ < 1厘米;大型.Results > = 1厘米)。我们研究了583 t2损伤(脑、512 (88 \ %); spinal cord, 71[12\%]) from 55 patients. At last MRI (median follow-up 54 months[IQR, 7-74]), 455 T2-lesions (78\%) resolved. The median (IQR) time to resolution was 3 months (1.4-7.0). Small T2-lesions resolved more frequently and faster than large T2-lesions. Acute T1-hypointesity decreased the likelihood (odds ratio[95\% confidence interval]) of T2-lesion resolution independent of size (small: 0.23[0.09, 0.60], p=0.002; large: 0.30[0.16, 0.55], p\<0.001) while acute steroids favored resolution of large T2-lesions (1.75[1.01, 3.03], p=0.046). Notably, 32/55 (58\%) T2-lesions resolved without treatment.Discussion. The high frequency of spontaneous T2-lesion resolution suggests this represents MOGAD{\textquoteright}s natural history. The speed of T2-lesion resolution and influence of size, corticosteroids and T1-hypointensity on this phenomenon gives insight into MOGAD pathogenesis.}, issn = {0028-3878}, URL = {//www.ebmtp.com/content/early/2023/06/16/WNL.0000000000207478}, eprint = {//www.ebmtp.com/content/early/2023/06/16/WNL.0000000000207478.full.pdf}, journal = {Neurology} }