% 0期刊文章% Yu-Chien吴%一个土卫五。祖卡罗尔不干了温家宝% %何晶杨%杰西卡·m·吉尔% Sujuan高%一个凯瑟琳·A·莱恩%蒂莫西·b·迈耶%拉里维Riggen %一个雅罗斯瓦夫Harezlak %克里斯托弗·c·吉萨%约书亚高盛%凯文·m·Guskiewicz %杰森·P·Mihalik % Stephen m . LaConte % Stefan m .杜马% Steven P Broglio %安德鲁j . Saykin % %迈克尔·托马斯·沃克麦卡利斯特麦克雷博士% T之间的纵向联系血液生物标志物和白质MRI在体育运动相关的脑震荡:研究NCAA-DoD保健财团% D R 10.1212 / WNL 2023%。0000000000207389 % J半岛投注体育官网神经病学% P 10.1212 / WNL。0000000000207389 % X目的研究纵向blood-based神经生物标志物之间的关联(包括总τ、光神经丝(NfL)、胶质原纤维酸性蛋白(GFAP)和泛素c端hydrolase-L1 (UCH-L1))和白质神经影像生物标志物在大学生运动员与体育运动相关的脑震荡(SRC)具有抑制受损return-to-play后1周延伸24小时。方法分析临床和影像数据有脑震荡的大学生运动员脑震荡的评估,研究和教育(保健)财团。关心参与者完成了当天的临床评估,血液吸引,和扩散张量成像(DTI)在三个时间点:具有抑制受损,延伸24 - 48小时之内变得无症状,return-to-play后7天。DTI概率为每个主题在每个时间点执行tractography呈现27个科目的主要白质束。这些大片的微观结构组织的特点是四DTI指标。Mixed-effects随机拦截模型应用于测试是否白质显微结构的异常与blood-based相关生物标记物在同一时间点。一个交互模型被用来测试如果协会在不同时间点。滞后模型用于测试如果blood-based早期生物标志物预测后显微结构的变化。77大学生运动员的数据结果包括在以下分析。4 blood-based中生物标志物,总τ有重大关联的DTI指标在三个时间点。特别是,τ径向扩散系数呈正相关(RD)对皮质脊髓束(β= 0.25,= 0.07,pFDR-adjusted = 0.016)和优越的丘脑的辐射(β= 0.21,= 0.07,pFDR-adjusted = 0.042)。 NfL and GFAP had time-dependent associations with the DTI metrics. NfL showed significant associations only at the asymptomatic time point (|β|s>0.12, SEs<0.09, psFDR-adjusted<0.05) and GFAP showed a significant association only at 7-days following return-to-play (βs>0.14, SEs<0.06, psFDR-adjusted<0.05). The p-values for the associations of early tau and later RD were not significant after multiple comparison adjustment, but were less than 0.1 in seven white-matter tracts.Conclusions This prospective study using data from the CARE Consortium demonstrated that in the early phase of SRC, white-matter microstructural integrity detected by DTI neuroimaging was associated with elevated levels of blood-based biomarkers of traumatic brain injury. Total tau in the blood showed the strongest association with white-matter microstructural changes. %U //www.ebmtp.com/content/neurology/early/2023/06/16/WNL.0000000000207389.full.pdf