@article {Sun10.1212 / WNL。0000000000207480,作者= {Jiangwei太阳和乔纳斯Halfvarson和彼得Appelros和大卫·伯格曼和法西姆Ebrahimi Bjorn Roelstraete Ola Ol {\ ' e} n和乔纳斯Ludvigsson}, title ={长期炎症性肠病的患者中风的风险:以人群为基础的Sibling-Controlled队列研究,1969 {\ textendash} 2019}, elocation-id = {10.1212 / WNL。={2023}0000000000207480},年,doi = {10.1212 / WNL。出版商0000000000207480}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景和目标:炎症性肠病(IBD)患者血栓栓塞事件的风险增加,但证据长期中风的风半岛投注体育官网险仍然稀缺。我们旨在探索一个活检确诊IBD患者是否增加长期患中风的风险。方法:本群包括所有活检确诊IBD患者在瑞典在1969年至2019年之间,以及五匹配参考个人每名患者被随机选择从一般人群和IBD-free完整的兄弟姐妹。主要结果是事件总体中风;二次结果缺血性和出血性中风。中风被确认来自瑞典国家利用初级和二级诊断病人登记。调整风险比率(明显)中风被灵活的参数生存模型估计。结果:共有85006名患者炎症性肠病(包括{\ textquoteright}年代克罗恩病(CD, n = 25257)、溃疡性结肠炎(UC, n = 47354)、和IBD-unclassified (IBD-U, n = 12395)], 406987匹配参考个人,101082 IBD-free完整的兄弟姐妹被包括在分析中。 We observed 3,720 incident strokes in IBD patients (incidence rate (IR)=32.6 per 10,000 person-years) and 15,599 in reference individuals (IR=27.7; aHR=1.13, 95\%CI: 1.08-1.17). The elevated aHR remained increased even 25 years after diagnosis, corresponding to one additional stroke case per 93 IBD patients until then. The excess aHR was mainly driven by ischaemic stroke (aHR=1.14; 1.09-1.18) rather than hemorrhagic stroke (aHR=1.06; 0.97-1.15). The risk for ischaemic stroke was significantly increased across IBD subtypes [CD (IR: 23.3 vs. 19.2; aHR=1.19; 1.10-1.29), UC (IR: 25.7 vs. 22.6; aHR=1.09; 1.04-1.16), and IBD-U (IR: 30.5 vs. 22.8; aHR=1.22; 1.08-1.37)]. Similar results were found when IBD patients were compared with their siblings.Discussion: Patients with IBD were at an increased risk of stroke, especially of ischaemic events, irrespective of the IBD subtype. The excess risk persisted even 25 years after diagnosis. These findings highlight the need for clinical vigilance about the long-term excess risk of cerebrovascular events in IBD patients.}, issn = {0028-3878}, URL = {//www.ebmtp.com/content/early/2023/06/14/WNL.0000000000207480}, eprint = {//www.ebmtp.com/content/early/2023/06/14/WNL.0000000000207480.full.pdf}, journal = {Neurology} }