RT期刊文章SR电子T1全球患病率和发病率的肌萎缩性脊髓侧索硬化症:系统回顾摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯10.1212 SP / WNL。半岛投注体育官网0000000000207474 10.1212 / WNL。0000000000207474 A1克里斯蒂娜·沃尔夫森A1丹尼尔E Gauvin A1 Foluso Ishola A1 Maryam Oskoui年2023 UL //www.ebmtp.com/conte半岛投注体育官网nt/early/2023/06/12/WNL.0000000000207474.abstract AB背景和目标:肌萎缩性脊髓侧索硬化症(ALS)是一种罕见的神经退行性疾病影响上下运动神经元。由于其稀缺性和快速进步的性质,研究肌萎缩性侧索硬化症的流行病学是具有挑战性的和全面的照片缺乏这种疾病的全球负担。本系统评价的目的是描述ALS的全球发病率和患病率。方法:我们搜查了Medline和Embase,全球健康,PsycInfo, Cochrane图书馆和CINAHL识别文章发表在1月1日,2010年和2021年5月6日。研究是基于人群的患病率和报告估计,发病率、死亡率和/或肌萎缩性侧索硬化症,是合格的列入。本文的重点是发病率和患病率。质量评估使用开发工具来评估方法进行相关的患病率和发病率的研究。本文是在普洛斯彼罗注册,CRD42021250559。结果:这搜索生成的6238篇文章,其中140被选为数据提取和质量评估。 Of these, 85 articles reported on incidence and 61 on prevalence of ALS. Incidence ranged from 0.26 per 100,000 person-years in Ecuador to 23.46 per 100,000 person-years in Japan. Point prevalence ranged from 1.57 per 100,000 in Iran to 11.80 per 100,000 in the United States. Many articles identified ALS cases from multiple data sources.Discussion: There is variation in reported incidence and prevalence estimates of ALS across the world. While registries are an important and powerful tool to quantify disease burden, such resources are not available everywhere. This results in gaps in reporting of the global epidemiology of ALS, as highlighted by the degree of variation (and quality) in estimates of incidence and prevalence reported in this review.

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