% 0期刊文章% Erika Molteni %的藤本植物桑托斯年代卡纳斯% Marie-Michele Briand %一个安娜Estraneo %卡科罗姆的字体%丽塔Formisano %一个奥利维亚Gosseries Ekaterina Fufaeva % %一个罗宾·豪沃思% Paola Lanteri % Gimena Ines Licandro %的温迪·l·麦基% Vigneswaran Veeramuthu山木% %帕梅拉·威尔逊%一个“贝丝S Slomine % DoC的特殊利益集团国际脑损伤协会(IBIA-DoC团体)% T范围检查诊断,预后和治疗儿科疾病的意识% D R 10.1212 / WNL 2023%。0000000000207473 % J半岛投注体育官网神经病学% P 10.1212 / WNL。0000000000207473 X %的背景和目标。全面指导诊断、预后和治疗儿科患者的意识障碍(文档)尚未公布。我们旨在总结现有证据为文档> 14天时间,以支持未来的发展孩子年龄在6个月到18 years.Methods指南。这个范围审查报告基于PRISMA-ScR指南。系统搜索确定从4数据库记录:PubMed、Embase, Cochrane图书馆和网络科学。摘要收到3-blind评论。相应的全文评为“作用”和报告数据不能发表在其他保留文章(即。,没有双报告)被确定和分配给5专题评估团队。全文综述了使用双盲的标准化形式。水平的证据分级,generated.Results总结性陈述。 On November 9, 2022, 2167 documents had been identified; 132 articles were retained, of which 33 (25%) were published over the last 5 years. Overall, 2161 individuals met the inclusion criteria; female patients were 527 of 1554 (33.9%) cases included, whose sex was identifiable. Of 132 articles, 57 (43.2%) were single case reports, and only 5 (3.8%) clinical trials; the level of evidence was prevalently low (80/132; 60.6%). Most studies included neurobehavioral measures (84/127; 66.1%), and neuroimaging (81/127; 63.8%); 59 (46.5%) were mainly related to diagnosis, 56 (44.1%) to prognosis, and 44 (34.6%) to treatment. Most frequently used neurobehavioral tools included the Coma Recovery Scale-Revised, Coma/Near Coma Scale, Level of Cognitive Functioning Assessment Scale and Post-Acute Level of Consciousness scale. Electroencephalography, event related potentials, structural computerized tomography and Magnetic Resonance Imaging were the most frequently used instrumental techniques. In 29/53 (54.7%) cases DoC improvement was observed, which was associated to treatment with amantadine.Discussion. The literature on pediatric DoCs is mainly observational, and clinical details are either inconsistently presented or absent. Conclusions drawn from many studies convey insubstantial evidence, and have limited validity, and low potential for translation in clinical practice. Despite these limitations, our work summarizes the extant literature and constitutes a base for future guidelines related to diagnosis, prognosis and treatment of pediatric DoCs. %U //www.ebmtp.com/content/neurology/early/2023/06/12/WNL.0000000000207473.full.pdf