@article {Molteni10.1212 / WNL。0000000000207473,作者= {Erika Molteni和藤本植物桑托斯卡纳斯和Marie-Mich {\ ' e} le Briand和安娜Estraneo和卡罗莱纳科罗姆的字体和丽塔Formisano Ekaterina Fufaeva和奥利维亚Gosseries罗宾·霍沃斯,Paola Lanteri和Gimena {\ ' e} S Licandro和温迪·l·麦基和Vigneswaran Veeramuthu和帕梅拉·威尔逊和“山木和贝丝年代Slomine和特殊利益集团在国际脑损伤协会的医生(IBIA-DoC团体)},title ={范围检查诊断,预后和治疗儿科疾病的意识},elocation-id = {10.1212 / WNL。={2023}0000000000207473},年,doi = {10.1212 / WNL。出版商0000000000207473}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景和目标。半岛投注体育官网全面指导诊断、预后和治疗儿科患者的意识障碍(文档)尚未公布。我们旨在总结现有证据与\ DoCs > 14天时间,以支持未来的发展孩子年龄在6个月到18 years.Methods指南。这个范围审查报告基于PRISMA-ScR指南。系统搜索确定从4数据库记录:PubMed、Embase, Cochrane图书馆和网络科学。摘要收到3-blind评论。相应的全文评为{\ textquotedblleft}作用{\ textquotedblright}和报告数据没有发表在任何其他保留文章(即。,没有双报告)被确定和分配给5专题评估团队。全文综述了使用双盲的标准化形式。 Level of evidence was graded, and summative statements were generated.Results. On November 9, 2022, 2167 documents had been identified; 132 articles were retained, of which 33 (25\%) were published over the last 5 years. Overall, 2161 individuals met the inclusion criteria; female patients were 527 of 1554 (33.9\%) cases included, whose sex was identifiable. Of 132 articles, 57 (43.2\%) were single case reports, and only 5 (3.8\%) clinical trials; the level of evidence was prevalently low (80/132; 60.6\%). Most studies included neurobehavioral measures (84/127; 66.1\%), and neuroimaging (81/127; 63.8\%); 59 (46.5\%) were mainly related to diagnosis, 56 (44.1\%) to prognosis, and 44 (34.6\%) to treatment. Most frequently used neurobehavioral tools included the Coma Recovery Scale-Revised, Coma/Near Coma Scale, Level of Cognitive Functioning Assessment Scale and Post-Acute Level of Consciousness scale. Electroencephalography, event related potentials, structural computerized tomography and Magnetic Resonance Imaging were the most frequently used instrumental techniques. In 29/53 (54.7\%) cases DoC improvement was observed, which was associated to treatment with amantadine.Discussion. The literature on pediatric DoCs is mainly observational, and clinical details are either inconsistently presented or absent. Conclusions drawn from many studies convey insubstantial evidence, and have limited validity, and low potential for translation in clinical practice. Despite these limitations, our work summarizes the extant literature and constitutes a base for future guidelines related to diagnosis, prognosis and treatment of pediatric DoCs.}, issn = {0028-3878}, URL = {//www.ebmtp.com/content/early/2023/06/12/WNL.0000000000207473}, eprint = {//www.ebmtp.com/content/early/2023/06/12/WNL.0000000000207473.full.pdf}, journal = {Neurology} }