RT期刊文章SR电子T1多基因易感性在中年高血压和认知能力的人没有中风和痴呆摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯10.1212 SP / WNL。半岛投注体育官网0000000000207427 10.1212 / WNL。0000000000207427 A1 Cyprien a河A1纳塔莉亚Szejko A1 Daniela Renedo A1 Rommell b Noche A1朱利安·n·阿科斯塔A1卡梅隆p两A1理查德Sharma A1维克多·m·Torres-Lopez A1山姆Payabvash A1亚当de Havenon A1凯文Navin Sheth A1托马斯·m·吉尔A1 Guido j .要求年2023 UL //www.ebmtp.com/content/early/2023/06/09/WNL.0000000000207427.abstract AB半岛投注体育官网背景和目标:越来越多的证据表明,高血压会导致痴呆的风险更高。高血压是一种高度遗传特征,和更高的多基因易感性高血压(PSH)与老年痴呆症的风险更高。我们测试的假设一个更高PSH导致更糟糕的认知在中年的人无痴呆的表现。证实这个假设将支持后续的研究集中于使用hypertension-related基因组信息risk-stratify中年人高血压发展之前。方法:我们进行了一个嵌套,横断面基因研究在英国生物库。痴呆和中风史的研究参与者被排除在外。我们把参与者归类为低(≤20百分位),中间,或高(≥80)PSH根据2的结果多基因风险评分的收缩压和舒张压(BP)与732个遗传风险变异数据生成。一般认知能力得分计算作为分析的第一个组件,包括五个认知测试的结果。主要分析集中在欧洲,和二次分析包括所有种族/民族。结果:UKB招募的502422名参与者中,48118(9.6%)完成了认知评价,其中包括42011名(8.4%)的欧洲血统。 Multivariable regression models using systolic BP-related genetic variants indicated that compared to study participants with low PSH, those with intermediate and high PSH had reductions of 3.9% (beta -0.039, SE 0.012) and 6.6% (beta -0.066, SE 0.014), respectively, in their general cognitive ability score (P<0.001). Secondary analyses including all race/ethnic groups and using diastolic BP-related genetic variants yielded similar results (P<0.05 for all tests). Analyses evaluating each cognitive test separately indicated that Reaction Time, Numeric Memory, and Fluid Intelligence drove the association between PSH and general cognitive ability score (all individual tests, P<0.05).Discussion: Among non-demented, community-dwelling, middle-aged Britons, a higher PSH is associated with worse cognitive performance. These findings suggest that genetic predisposition to hypertension influences brain health in persons who have not yet developed dementia. Because information on genetic risk variants for elevated BP is available long before the development of hypertension, these results lay the foundation for further research focused on using genomic data for the early identification of high-risk middle-aged adults.