RT期刊文章SR电子T1早期临床变量与难治性惊厥的儿童癫痫持续状态的摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯10.1212 SP / WNL。半岛投注体育官网0000000000207472 10.1212 / WNL。0000000000207472 A1卡特里娜Peariso A1 Ravindra Arya A1特雷西朱丽恩A1尼古拉斯·S .异常终止A1克里斯蒂娜Barcia Aguilar A1 Marta Amengual-Gual A1 A1布莱恩·l·安德森Appavu A1 j . Nicholas Brenton A1杰西卡木匠A1凯文·E·查普曼A1大法官威廉克拉克A1 D盖拉德A1滨Gainza-Lein A1约书亚·戈尔茨坦A1霍华德Goodkin A1 Zachary Grinspan A1 Rejean m . Guerriero A1 Paul S .角A1琳达啊A1罗伯特Kahoud A1萨拉凯利科索夫A1 Eric H A1库什Kapur A1 Yi-Chen赖A1 b Oyinkan侯爵A1此举麦克唐纳A1穆罕默德米卡提A1林赛摩根A1爱德华Novotny A1亚当·p·Ostendorf A1埃里克·T佩恩A1胡安Piantino A1詹姆斯·里维耶洛A1特里斯坦金沙A1 Tasker Carl E Stafstrom A1罗伯特C A1德米特里Tchapyjnikov A1 Alejandra Vasquez-Avila A1马克年代温赖特A1安格斯威尔福格A1 Korwyn威廉姆斯A1 Tobias Loddenkemper A1对小儿癫痫持续状态研究小组(pSERG)年2023 UL //www.ebmtp.com/content/early/2023/06/09/WNL.0000000000207472.abstract AB目的:确定针对病人的急救护理的因素已知近似表示与耐火材料的发展,抽搐的癫痫持续状态(交易所)的孩子。半岛投注体育官网方法:一项观察病例对照研究比较儿科患者(1月- 21年)惊厥的SE发作停止后的苯二氮卓类(BZD)和一个二线抗癫痫药物(ASM)(响应建立癫痫持续状态;复位)患者需要一个多BZD和一个二线ASM停止他们的癫痫(交易所)。这些群体从小儿癫痫持续状态获得研究小组(pSERG)研究队列。我们探索临床变量,可以获得早期演讲后紧急医疗服务与单变量分析的原始数据。变量p < 0.1保留了单变量和多变量回归分析。多变量逻辑回归模型适合年龄和性别匹配的数据获取与交易所相关变量。结果:我们比较的数据共595集的小儿。单变量分析表明没有差异,第一个BZD(低于16分钟(差5-45);复位18分钟(IQR 6-44), p = 0.068)。时间二线ASM在证交所短患者(低于65分钟; rESE 70 min; p=0.021). Both univariable and multivariable regression analysis revealed a family history of seizures (OR 0.37; 95% CI 0.20 -0.70, p = 0.0022) or a prescription for rectal diazepam (OR 0.21; 95% CI 0.078 - 0.53, p = 0.0012) were associated with decreased odds of RSE.Conclusions: Time to initial BZD or second-line ASM was not associated with progression to RSE in our cohort of patients with rESE. A family history of seizures and a prescription for rectal diazepam were associated with a decreased likelihood of progression to RSE. Early attainment of these variables may help care for pediatric rESE in a more patient-tailored manner.COE: This study provides class II evidence that patient and clinical factors may predict RSE in children with convulsive seizures.

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