TY -的T1 -花生四烯酸协会Acid-Derived脂质介质与疾病严重程度患者复发和进展型多发性硬化症JF -神经学乔-神经- 10.1212 / WNL。半岛投注体育官网0000000000207459 SP - 10.1212 / WNL。0000000000207459 AU - Jelle y Broos AU -楼c . Loonstra盟德·鲁伊特Lodewijk R.J. AU -玛利亚姆M.T.E.E.豪达盟翼庆熙Fung AU - Menno m . Schoonheim盟Marieke Heijink AU - Eva M.M. Strijbis AU -夏洛特Teunissen盟•Killestein AU -海尔格e . de Vries盟Martin a . Giera AU -伯纳德M.J. Uitdehaag盟吉斯Kooij设计Y1 - 2023/06/08 UR - //www.ebmtp.com/content/early/2023/06/08/WNL.0000000000207459.abstract N2 -背景和半岛投注体育官网目标:某些脂类中介(LM)通路的过度激活在复杂的发病机理中发挥作用的多发性硬化症(MS)。然而,生物活性之间的关系LMs和CNS-related病理生理过程的不同方面在很大程度上仍是个未知数。因此,我们这里评估协会生物活性属于ω-3 LMs /ω-6脂类与临床、生化(血清神经丝光(sNfL)和血清胶质原纤维酸性蛋白(sGFAP))参数和mri脑容量(pwm)女士和健康对照组患者(HC)。方法:有针对性的高效液相chromatography-tandem质谱(HPLC-MS / MS)方法用于等离子体样品的pwm和HC的项目Y世代,基于人口横断面的队列,包含所有1966年生于荷兰和pwm与高碳钢。LMs比较pwm和HC之间与水平的sNfL sGFAP、残疾(eds)和脑容量。最后,重要的关联是包含在一个落后的多元回归模型来确定哪些LMs最佳相关的残疾。结果:研究样本包括170名复发患者汇款女士(名RRMS), 115名患者(PMS)和125 HC女士与进步。LM的PMS患者明显不同于名RRMS HC,特别是,经前综合症患者显示高浓度的几个花生四烯酸(AA)衍生品。特别是15-HETE (r = 0.24, p & lt;0.001),呈正相关(r = 0.2, p & lt;0.05)与eds和sNfL等临床和生化参数。 In addition, higher 15-HETE levels were related to lower total brain (r = -0.24, p = 0.04) and deep gray matter volumes (r = -0.27, p = 0.02) in patients with PMS and higher lesion volume (r = 0.15, p = 0.03) in all PwMS.Discussion: In PwMS of the same birth year, we show that ω-3 and -6 LMs are associated with disability, biochemical (sNfL, GFAP) and MRI measures. Furthermore, our findings indicate that particularly in patients with PMS, elevated levels of specific products of the AA pathway, such as 15-HETE, associate with neurodegenerative processes. Our findings highlight the potential relevance of ω-6 LMs in the pathogenesis of MS. ER -