PT -期刊文章AU -阿尔文·S Das盟Elif Gokcal AU -亚历山德罗Biffi盟罗伯特W Regenhardt AU -马可·帕斯盟阿维亚Abramovitz Fouks AU - Anand Viswanathan盟约书亚·戈尔茨坦盟-李h . Schwamm盟-乔纳森Rosand AU -史蒂文·M·格林伯格盟- M . Edip Gurol TI -机械的影响皮质表面铁尘肺患者的混合位置脑出血和脑- 10.1212 / WNL Microbleeds援助。0000000000207476 DP - 2023 6月08年TA -神经病半岛投注体育官网学PG - 10.1212 / WNL。0000000000207476 4099 - http://n.半岛投注体育官网neurology.org/content/early/2023/06/08/WNL.0000000000207476.short 4100 - //www.ebmtp.com/content/early/2023/06/08/WNL.0000000000207476.full AB -背景和目的:高血压脑小血管疾病患者(HTN-cSVD)是主要的微血管病叶的和深脑microbleeds (CMBs)和脑出血(和我)。我们测试的假设脑淀粉样血管病(CAA)也是一个促进微血管病混合我大脑皮层表面的铁尘肺患者(cSS),一个标记与创新艺人经纪公司密切相关。方法:从数据库未来的大脑核磁共振成像的连续非创伤性综述了我的病人转诊中心的CMBs, cSS和non-hemorrhagic CAA标记(大叶性可见,中枢semiovale扩大血管周的空间(CSO-EPVS)(负责人)和multispot白质高密度模式)。创新艺人经纪公司的频率标记和左心室肥厚(LVH)的标记终末器官的损伤,高血压患者之间比较复杂的我cSS(混合我/ cSS[+]),没有cSS(混合我/ cSS[-])在单变量和多变量模型。结果:1791我的病人,40我喜忧参半/ cSS(+)和256年混合我/ cSS (-)。LVH是不太常见的混合我/ cSS(+)患者相比,混合我/ cSS(-)(34%比59%,p = 0.01)。CAA成像标记的频率,即multispot模式(18%比4%,p & lt;0.01)和严重CSO-EPVS(33%比11%,p & lt;0.01),高混合我/ cSS(+)患者相比,混合我/ cSS (-)。在逻辑回归模型中,老年(aOR每年1.04,95%可信区间(1.00 - -1.07),p = 0.04),缺乏LVH(优势比为0.41,95%可信区间(0.19 - -0.89),p = 0.02), multispot负责人模式(优势比为5.25,95%可信区间(1.63 - -16.94),p = 0.01),和严重的中枢semiovale EPVS(优势比为4.24,95%可信区间(1.78 - -10.13),p & lt; 0.01) were independently associated with mixed ICH/cSS(+) after further adjustment for hypertension and coronary artery disease. Among ICH survivors, the adjusted hazard ratio of ICH recurrence in mixed ICH/cSS(+) patients was 4.65 (95% CI [1.38–11.38], p < 0.01) compared to mixed ICH/cSS(–) patients.Discussion: The underlying microangiopathy of mixed ICH/cSS(+) likely includes both HTN-cSVD and CAA, whereas mixed ICH/cSS(–) is likely driven by HTN-cSVD. These imaging-based classifications can be important to stratify ICH risk, but warrant confirmation in studies incorporating advanced imaging/pathology.