PT -期刊文章盟Wi-Sun Ryu AU -金庸聪盟Dawid Schellingerhout AU - Sang-Wuk Jeong盟Hang-Rai金盟荣格大肠公园盟- Beom俊金盟这样说道Joon-Tae金盟Keun-Sik香港非盟- Kyungbok李盟盟泰青紫色公园- Sang-Soon公园盟盟Jong-Moo公园- Kyusik康盟- Yong-Jin赵盟盟Hong-Kyun公园Byung-Chul李盟- Yu庆浩盟- Mi太阳哦,非盟- Joo -秀李盟Cha - Jae鞠觉亮金盟Jae-Kwan AU - Dae-Hyun金盟君李盟盟- Moon-Ku汉盟人Seok公园-崔Kang-Ho盟Juneyoung李盟金- Hee-Joon Bae盟Dong-Eog TI -生物机制中风性别差异的表现和结果- 10.1212 / WNL的援助。0000000000207346 DP - 2023年6月13日TA -神经病半岛投注体育官网学PG - e2490 e2503 VI - 100 IP - 24 4099 - //www.ebmtp.com/content/100/24/e2490.short 4100 - //www.ebmtp.com/content/100/24/e2490.full所以Neurology2023 6月13;100 AB -背景和目标女性患者往往有更大的残疾和卒中后长期的结果比男性患者。到目前为止,性别差异在缺血性中风的生物学基础尚不清楚。我们旨在(1)评估性别差异在急性缺血性中风的临床表现和结果,(2)探讨性别差异是否由于梗塞不同梗塞位置或不同的影响在同一位置。方法连续mri多中心研究包括6464急性缺血性中风患者(& lt; 7天)从11个中心在韩国(2011年5月- 2013年1月)。多变量统计和大脑映射方法被用来分析临床和影像前瞻性收集的数据:入学NIH卒中量表(署)得分,早期神经功能恶化(结束)后3周内,改良Rankin规模(夫人)得分为3个月,而罪魁祸首脑血管病变(大型动脉steno-occlusion症状和脑梗塞)的位置。结果平均为67.5(12.6)岁(SD),和2641年(40.9%)是女性患者。梗死体积百分比diffusion-weighted MRI上没有男性患者和女性患者之间差异(平均0.14%比0.14%,p = 0.35)。然而,女性患者显示更高的中风严重性(署分数,平均4和3,p & lt;0.001)和更频繁的结束(调整差异3.5%;比男性患者p = 0.002)。女性患者更频繁striatocapsular病变(43.6%比39.8%,p = 0.001),减少频繁cerebrocortical(52岁以上的患者中48.2%比50.7%,p = 0.06)和小脑(9.1%比11.1%,p = 0.009)比男性患者,病变与血管造影发现:女性患者症状更普遍的steno-occlusion大脑中动脉(MCA) (31.1% vs 25.3%; p < 0.001) compared with male patients, who had more frequent symptomatic steno-occlusion of the extracranial internal carotid artery (14.2% vs 9.3%; p < 0.001) and vertebral artery (6.5% vs 4.7%; p = 0.001). Cortical infarcts in female patients, specifically left-sided parieto-occipital regions, were associated with higher NIHSS scores than expected for similar infarct volumes in male patients. Consequently, female patients had a higher likelihood of unfavorable functional outcome (mRS score >2) than male patients (adjusted absolute difference 4.5%; 95% CI 2.0–7.0; p < 0.001).Discussion Female patients have more frequent MCA disease and striatocapsular motor pathway involvement with acute ischemic stroke, along with left parieto-occipital cortical infarcts showing greater severity for equivalent infarct volumes than in male patients. This leads to more severe initial neurologic symptoms, higher susceptibility to neurologic worsening, and less 3-month functional independence, when compared with male patients.AAL=Automated Anatomical Labeling; ACA=anterior cerebral artery; CE=cardioembolism; CRCS-K=Clinical Research Collaboration for Stroke–Korea; DWI=diffusion-weighted image; END=early neurological deterioration; FLAIR=fluid-attenuated inversion recovery; ICA=internal carotid artery; JHU=Johns Hopkins University; LAA=large artery atherosclerosis; MCA=middle cerebral artery; mRS=modified Rankin Scale; NIHSS=NIH Stroke Scale; NNT=number needed to treat; ROI=region of interest; SVO=small vessel occlusion; WMH=white matter hyperintensity