% 0期刊文章%伊丽莎白·库恩%一个奥黛丽Perrotin % Renaud La乐趣%雪绒花Touron %一个苏菲Dautricourt %马修Vanhoutte %丹尼斯薇薇安%文森特de La Sayette %盖尔人Chetelat %为阿尔茨海默病的神经影像学% T协会Informant-Reported与认知和大脑记忆衰退恶化通过老年痴呆症临床连续% D R 10.1212 / WNL 2023%。0000000000207338 % J半岛投注体育官网神经病学% P e2454-e2465 % V 100% N 24% X研究稀疏的有关背景和目标之间的关联informant-reported主观记忆衰退(线人报告)和阿尔茨海默病(AD)生物标志物。因此本研究旨在确定的临床相关性线人报告整个广告临床连续体,通过评估其特定的与淀粉样蛋白沉积的关系,认知和神经退化。方法从Imagerie参与者Multimodale de la病d 'Alzheimer联合国施塔德Precoce (IMAP +)初级群体和阿尔茨海默病神经影像倡议(ADNI)复制队列中;进行了多通道神经影像学和神经心理评估。后续数据IMAP +参与者/ 36个月也用于纵向分析。线人报告测量的认知困难量表(IMAP +)和日常认知(ADNI)。一般线性模型被用来评估之间的横向联系线人报告和淀粉pet,认知表现,和神经退行性变的老年痴呆症的签名(萎缩和代谢减退);而纵向联系在IMAP +线性mixed-effects模型评估。结果总共包括110 IMAP +参与者,包括32个认知未受损伤的老年人(控制、年龄:70.91±6.57岁,女:50%),25名患者主观认知能力下降(SCD, 65.88±6.64, 40%)、35岁患有轻度认知障碍(MCI, 72.49±7.5, 34%)和18 Alzheimer-type痴呆(AD痴呆,68.17±8.59,28%)。七百三十一包括ADNI参与者,包括157名对照(74.21±5.95,55%),84年SCD(72.00±5.41, 63%), 369年与MCI(71.84±7.4, 44%),和121 AD痴呆(74.29±7.75,40%)。在IMAP +,更高的线人报告更大的淀粉pet有着密切的联系,特别是在MCI患者(β= 0.48,p = 0.003),并降低SCD患者认知能力(全球认知,β=−0.41,p = 0.04)和MCI(记忆,β=−0.37,p = 0.03)。 Findings in patients with MCI were replicated in the ADNI (amyloid-PET, β = 0.25, p < 0.001; memory, β = −0.22, p < 0.001) and extended to neurodegeneration in AD signature areas (β = −0.2, p < 0.001). Longitudinal analyses in IMAP+ showed links with global cognitive decline over time in patients with MCI (estimate −0.74, SE 0.26, p = 0.005) and SCD (estimate −0.36, SE 0.26, p = 0.02) where a higher baseline informant report also predicted an increased amyloid-PET over time (estimate 0.008, SE 0.003, p = 0.02).Discussion Altogether, our findings suggest that the informant report is particularly relevant in patients with MCI where it strongly relates to higher amyloid-PET, indicative of impairment due to AD.Trial Registration Information ClinicalTrials.gov Identifier: NCT01638949.AD dementia=Alzheimer-type dementia; ADNI=Alzheimer Disease Neuroimaging Initiative; CDS=Cognitive Difficulties Scale; CU=cognitively unimpaired; ESR=Encoding, Storage, and Retrieval; FDG=18F-fluorodeoxyglucose; FDR=false discovery rate; FLAIR=fluid-attenuated inversion recovery; GM=gray matter; IMAP+=Imagerie Multimodale de la maladie d'Alzheimer à un stade Précoce; I-SMD=Informant-reported Subjective Memory Decline; MCI=mild cognitive impairment; MMSE=Mini-Mental State Examination; SCD=subjective cognitive decline; Self-SMD=self-reported Subjective Memory Decline; SUVr=global neocortical standardized uptake value ratio %U //www.ebmtp.com/content/neurology/100/24/e2454.full.pdf