TY -的T1 -协会Mediterranean-DASH干预神经退行性延迟和地中海饮食与阿尔茨海默病病理JF -神经学乔-神经病学SP - e2259 LP - e2268做- 10.1212 / WNL。半岛投注体育官网0000000000207176六世- 100 - 22盟供Agarwal AU -苏大肠Leurgans盟声速的Agrawal AU - Neelum t . Aggarwal盟月桂j . Cherian AU -布莱恩·d·詹姆斯盟Klodian Dhana AU -丽莎·l·巴恩斯AU -大卫·a·班尼特盟朱莉·a·施耐德Y1 - 2023/05/30 UR - //www.ebmtp.com/content/100/22/e2259.abstract N2 -背景和目标的饮食可以降低老年痴呆症风险和减缓认知能力的衰退,但半岛投注体育官网有关neuropathologic机制的理解仍然有限。协会的饮食模式与阿尔茨海默病(AD)病理学建议使用神经影像生物标志物。本研究调查了协会Mediterranean-DASH干预神经退行性延迟(思想)和地中海饮食模式与β-amyloid负载,磷酸化τ缠结,和全球广告的老年人死亡的脑组织病理学。方法解剖参与者的拉什记忆和衰老项目完整的饮食信息(通过验证食物频率问卷收集)和AD病理数据(β-amyloid负载、磷酸化τ缠结和全球广告病理学(神经原纤维缠结和神经炎的总结和弥漫性斑块))被纳入本研究。线性回归模型控制死亡年龄,性别,教育,APOE-ε4状态和总热量被用来调查饮食模式(思想和地中海饮食)和饮食组件与AD病理相关。进一步修改检测APOE-ε4地位和性的影响。结果我们的研究参与者(N = 581,死亡年龄:91.0±6.3年;平均年龄首先膳食评价:84.2±5.8年;73%的女性; 6.8 ± 3.9 years of follow-up), dietary patterns were associated with lower global AD pathology (MIND: β = −0.022, p = 0.034, standardized β = −2.0; Mediterranean: β = −0.007, p = 0.039, standardized β = −2.3) and specifically less β-amyloid load (MIND: β = −0.068, p = 0.050, standardized β = −2.0; Mediterranean: β = −0.040, p = 0.004, standardized β = −2.9). The findings persisted when further adjusted for physical activity, smoking, and vascular disease burden. The associations were also retained when participants with mild cognitive impairment or dementia at the baseline dietary assessment were excluded. Those in the highest tertile of green leafy vegetables intake had less global AD pathology when compared with those in the lowest tertile (tertile 3 vs tertile 1: β = −0.115, p = 0.0038).Discussion The MIND and Mediterranean diets are associated with less postmortem AD pathology, primarily β-amyloid load. Among dietary components, higher green leafy vegetable intake was associated with less AD pathology.AD=Alzheimer disease; FFQ=food frequency questionnaire; MAP=Memory and Aging Project; MCI=mild cognitive impairment; MIND=Mediterranean-DASH Intervention for Neurodegenerative Delay; PiB-PET=Pittsburgh compound B positron emission tomography ER -