TY - T1的妊娠高血压疾病协会与认知在晚年JF -神经学乔-神经病学SP - e2017 LP - e2026做- 10.1212 / WNL。半岛投注体育官网0000000000207134六世- 100 - 19 AU -米歇尔·m·Mielke盟瑞安·d·弗兰克AU -卢克·r·克里盟Julie a .字段非盟-沃尔特·a·罗卡盟维斯纳d Garovic Y1 - 2023/05/09 UR - //www.ebmtp.com/content/100/19/e2017.abstract N2 -背景和目标研究妊娠高血压疾病(黄半岛投注体育官网芪丹参滴丸),包括妊娠期或慢性高血压(GH / CH)和子痫前期/子痫(PE / E),建议对幼年时期和中年认知有限但一直自我报告或使用的诊断代码,排除未生育过的女性,和缺乏认知的测量。我们检查的影响任何黄芪丹参滴丸,GH / CH, PE / E,未产妇认知。方法参与者包括2239名妇女(平均年龄73)进入衰老的梅奥诊所研究与医学record-abstracted怀孕信息。认知电池9每15个月进行了测试。全球认知和特定领域的z分数(内存,执行/注意力、视觉空间的和语言)的结果。线性混合效应模型评估怀孕之间的联系历史(血压正常的人,任何HPD, HPD亚型(GH / CH、PE / E),或未生育过的)和认知能力下降,调整了年龄和教育。额外的模型调整的APOE、吸烟、高血压、血脂异常、体重指数(BMI)、糖尿病、中风和心脏病。怀孕之间的交互历史和年龄或教育认知性能检查。结果的2239名妇女中,1854(82.8%)至少有1怀孕(1607所有的血压正常的人,100 GH / CH,和147年PE / E); 385 (17.2%) were nulliparous. Cognitive performance did not cross-sectionally differ for women with a history of any HDP, GH/CH, or PE/E vs women with a history of all normotensive pregnancies; women who were nulliparous had lower global and domain-specific cognition (all p < 0.05) in age- and education-adjusted models. There was an interaction (p = 0.015) between nulliparity and education such that the lower cognitive performance was most pronounced among nulliparous women with ≤12 years of education (beta = −0.42, p < 0.001) vs 12 + years (b = −0.11, p = 0.049). Longitudinally, women with any HDP had greater declines in global cognition and attention/executive z scores compared with women with all normotensive pregnancies. When stratified by HDP type, only women with PE/E had greater declines in global cognition (beta = −0.04, p < 0.001), language (beta = −0.03, p = 0.001), and attention (beta = −0.04, p < 0.001) z scores. Adjustment for vascular risk factors, BMI, smoking, and APOE did not attenuate results.Discussion Women with a history of HDP, especially PE/E, are at greater risk of cognitive decline in later life.BMI=body mass index; CU=cognitively unimpaired; DM=diabetes mellitus; GH/CH=gestational or chronic hypertension; HDP=hypertensive disorders of pregnancy; HTN=hypertension; MCI=mild cognitive impairment; MCSA=Mayo Clinic Study of Aging; PE/E=preeclampsia/eclampsia; PRES=posterior reversible encephalopathy syndrome; REP=Rochester Epidemiology Project ER -