% 0期刊文章%米歇尔·m . Mielke % Ryan D·弗兰克% % Julie A .字段%现已卢克·R·克里斯坦森沃尔特·A·罗卡%维斯纳D Garovic % T妊娠高血压疾病协会晚年认知% D R 10.1212 / WNL 2023%。0000000000207134 % J半岛投注体育官网神经病学% P e2017-e2026 % V 100% N 19% X背景和目标研究妊娠高血压疾病(黄芪丹参滴丸),包括妊娠期或慢性高血压(GH / CH)和子痫前期/子痫(PE / E),建议对幼年时期和中年认知但一直受制于自我报告或使用的诊断代码,排除未生育过的女性,和缺乏认知的测量。我们检查的影响任何黄芪丹参滴丸,GH / CH, PE / E,未产妇认知。方法参与者包括2239名妇女(平均年龄73)进入衰老的梅奥诊所研究与医学record-abstracted怀孕信息。认知电池9每15个月进行了测试。全球认知和特定领域的z分数(内存,执行/注意力、视觉空间的和语言)的结果。线性混合效应模型评估怀孕之间的联系历史(血压正常的人,任何HPD, HPD亚型(GH / CH、PE / E),或未生育过的)和认知能力下降,调整了年龄和教育。额外的模型调整的APOE、吸烟、高血压、血脂异常、体重指数(BMI)、糖尿病、中风和心脏病。怀孕之间的交互历史和年龄或教育认知性能检查。结果的2239名妇女中,1854(82.8%)至少有1怀孕(1607所有的血压正常的人,100 GH / CH,和147年PE / E); 385 (17.2%) were nulliparous. Cognitive performance did not cross-sectionally differ for women with a history of any HDP, GH/CH, or PE/E vs women with a history of all normotensive pregnancies; women who were nulliparous had lower global and domain-specific cognition (all p < 0.05) in age- and education-adjusted models. There was an interaction (p = 0.015) between nulliparity and education such that the lower cognitive performance was most pronounced among nulliparous women with ≤12 years of education (beta = −0.42, p < 0.001) vs 12 + years (b = −0.11, p = 0.049). Longitudinally, women with any HDP had greater declines in global cognition and attention/executive z scores compared with women with all normotensive pregnancies. When stratified by HDP type, only women with PE/E had greater declines in global cognition (beta = −0.04, p < 0.001), language (beta = −0.03, p = 0.001), and attention (beta = −0.04, p < 0.001) z scores. Adjustment for vascular risk factors, BMI, smoking, and APOE did not attenuate results.Discussion Women with a history of HDP, especially PE/E, are at greater risk of cognitive decline in later life.BMI=body mass index; CU=cognitively unimpaired; DM=diabetes mellitus; GH/CH=gestational or chronic hypertension; HDP=hypertensive disorders of pregnancy; HTN=hypertension; MCI=mild cognitive impairment; MCSA=Mayo Clinic Study of Aging; PE/E=preeclampsia/eclampsia; PRES=posterior reversible encephalopathy syndrome; REP=Rochester Epidemiology Project %U //www.ebmtp.com/content/neurology/100/19/e2017.full.pdf