PT -期刊文章盟Wookjin阳盟Keun-Hwa荣格AU -东莞康盟Eung-Joon李盟Han-Yeong宋AU -马修涌盟Youngjoon金盟Jiyeon Ha AU - Jeong-Min金盟Seung-Hoon李TI -特征和临床意义的白质病变患者的成人烟雾病- 10.1212 / WNL援助。0000000000207130 DP - 2023年5月02 TA -神经病半岛投注体育官网学PG - e1912 e1921 VI - 100 IP - 18 4099 - //www.ebmtp.com/content/100/18/e1912.short 4100 - //www.ebmtp.com/content/100/18/e1912.full所以Neurology2023可能02;100 AB -背景和目标白质hyperintensities(负责人)据报道,增加性烟雾病(MMD);然而,他们的临床重要性并不完善的由于他们的病理生理的异质性分布。本研究旨在评估负责人的负担和模式在多党民主运动轨迹及其临床意义。方法成人多党民主运动没有重大结构性病变患者1:1倾向与健康对照组score-matched性和血管危险因素。总、室,皮层下负责人卷自动分割和量化完全。研究负责人卷被年龄去趋势两组之间的比较。多党民主运动基于铃木阶段和未来缺血性事件严重程度与负责人进行了评估卷。结果共有161对患者多党民主运动和控制进行了分析。多党民主运动与负责人总额增加显著相关(B(标准误差),0.126 (0.030);p & lt; 0.001), periventricular WMH volume (0.114 [0.027]; p < 0.001), and periventricular-to-subcortical ratio (0.090 [0.034]; p = 0.009). In the MMD subgroup (n = 187), advanced MMD had an independent association with the total WMH volume (0.120 [0.035]; p < 0.001), periventricular WMH volume (0.110 [0.031]; p < 0.001), and periventricular-to-subcortical ratio (0.139 [0.038]; p < 0.001). Periventricular WMH volume (adjusted hazard ratio [95% confidence interval], 5.12 [1.26–20.79]) and periventricular-to-subcortical ratio (3.80 [1.51–9.56]) were associated with future ischemic events in patients with medically followed up MMD. However, no demonstrable association was found between subcortical WMH volume and MMD, MMD severity, or future ischemic events.Discussion Periventricular WMHs, but not subcortical WMHs, may represent the main pathophysiology of MMD. Periventricular WMHs may be used as a marker for ischemic vulnerability in patients with MMD.FSPGR=fast spoiled gradient echo; MMD=moyamoya disease; MPRAGE=magnetization prepared rapid gradient echo; TFE=turbo field echo; TIA=transient ischemic attack; WMH=White matter hyperintensities