RT期刊文章SR电子T1 Tenecteplase安全性和有效性和溶栓串联病变患者中风摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP e1900 OP e1911 10.1212 / WNL。半岛投注体育官网100签证官0000000000207138是18 A1 Vignan Yogendrakumar A1狮子座Churilov A1 Peter j .米切尔A1 (Timothy j . Kleinig A1 Nawaf Yassi A1文森特Thijs A1泰迪吴A1沾光沙A1彼得·贝利A1海伦·m·杜威A1菲利普·贝拉崔A1爱丽丝马A1 Tissa韦杰A1卡洛斯Garcia-Esperon A1杰弗里云A1 Ronil诉钱德拉A1 Dennis j . Cordato A1伯纳德燕A1选手Gagan Sharma A1帕特里夏·m·德斯蒙德马克·w·帕森斯A1 A1杰弗里·a·唐南A1斯蒂芬·m·戴维斯A1布鲁斯坎贝尔的简历A1的EXTEND-IA秋明石油公司调查人员年2023 UL //www.ebmtp.com/content/100/18/e1900.abstract AB背景和目标的安全性和有效性tenecteplase(秋明石油公司)串联病变患者(TL)中风是未知的。半岛投注体育官网我们进行一个比较分析秋明石油公司和患者溶栓TLs。方法:我们首先比较秋明石油公司的治疗效果和患者的溶栓TLs使用EXTEND-IA秋明石油公司个体患者数据试验。我们在初始评估颅内再灌注血管造影评估和90天的改良Rankin规模(夫人)序数物流和弗斯回归模型。因为2关键结果,死亡率和症状性颅内出血(西奇),数量很少,在那些接受溶栓在EXTEND-IA秋明石油公司试验,我们生成的汇集估计这些结果通过补充试验数据估计入射通过荟萃分析研究确定在系统回顾。然后计算未经调整的风险差异比较集中发病率估计对于那些接受溶栓试验中观察到的那些接收秋明石油公司。结果七十一483名患者(15%)的患者拥有一个TL EXTEND-IA秋明石油公司试验。TLs,观察颅内再灌注在11/56(20%)的TNK-treated病人vs 1/15 (7%) alteplase-treated病人(调整后的优势比2.19;95%可信区间0.28 - -17.29)。无显著差异在观察90天的夫人(共同调整优势比1.48; 95% CI 0.44–5.00). A pooled study-level proportion of alteplase-associated mortality and sICH was 0.14 (95% CI 0.08–0.21) and 0.09 (95% CI 0.04–0.16), respectively. Compared with a mortality rate of 0.09 (95% CI 0.03–0.20) and an sICH rate of 0.07 (95% CI 0.02–0.17) in TNK-treated patients, no significant difference was observed.Discussion Functional outcomes, mortality, and sICH did not significantly differ between patients with TLs treated with TNK and those treated with alteplase.Classification of Evidence This study provides Class III evidence that TNK is associated with similar rates of intracranial reperfusion, functional outcome, mortality, and sICH compared with alteplase in patients with acute stroke due to TLs. However, the CIs do not rule out clinically important differences.Trial Registration Information clinicaltrials.gov/ct2/show/NCT02388061; clinicaltrials.gov/ct2/show/NCT03340493.CTA=CT angiography; DSA=digital subtraction angiography; eICA=extracranial internal carotid artery; eTICI=extended treatment in cerebral ischemia; LVO=large vessel occlusion; mRS=modified Rankin scale; NIHSS=NIH Stroke Scale; sICH=symptomatic intracranial hemorrhage; TL=tandem lesion; TNK=tenecteplase