PT -期刊文章盟Vignan Yogendrakumar盟Peter j .米切尔-狮子座Churilov盟盟——蒂莫西·j·Kleinig盟Nawaf Yassi AU -文森特Thijs AU -泰迪吴盟沾光沙非盟-彼得·贝利盟-海伦·m·杜威AU -菲利普·贝拉崔AU -马爱丽丝盟Tissa韦杰云盟盟-卡洛斯Garcia-Esperon盟杰弗里- Ronil诉钱德拉盟Dennis j . Cordato AU -伯纳德燕盟选手Gagan Sharma盟马克·w·帕森斯-帕特里夏·m·德斯蒙德盟盟——杰弗里·a·唐南盟——斯蒂芬·m·戴维斯AU -布鲁斯坎贝尔的简历盟EXTEND-IA秋明石油公司的调查员Tenecteplase TI -安全性和有效性和溶栓串联病变患者中风- 10.1212 / WNL的援助。0000000000207138 DP - 2023年5月02 TA -神经病半岛投注体育官网学PG - e1900 e1911 VI - 100 IP - 18 4099 - //www.ebmtp.com/content/100/18/e1900.short 4100 - //www.ebmtp.com/content/100/18/e1900.full所以Neurology2023可能02;100 AB -背景和目标的安全性和有效性tenecteplase(秋明石油公司)串联病变患者(TL)中风是未知的。我们进行一个比较分析秋明石油公司和患者溶栓TLs。方法:我们首先比较秋明石油公司的治疗效果和患者的溶栓TLs使用EXTEND-IA秋明石油公司个体患者数据试验。我们在初始评估颅内再灌注血管造影评估和90天的改良Rankin规模(夫人)序数物流和弗斯回归模型。因为2关键结果,死亡率和症状性颅内出血(西奇),数量很少,在那些接受溶栓在EXTEND-IA秋明石油公司试验,我们生成的汇集估计这些结果通过补充试验数据估计入射通过荟萃分析研究确定在系统回顾。然后计算未经调整的风险差异比较集中发病率估计对于那些接受溶栓试验中观察到的那些接收秋明石油公司。结果七十一483名患者(15%)的患者拥有一个TL EXTEND-IA秋明石油公司试验。TLs,观察颅内再灌注在11/56(20%)的TNK-treated病人vs 1/15 (7%) alteplase-treated病人(调整后的优势比2.19;95%可信区间0.28 - -17.29)。无显著差异在观察90天的夫人(共同调整优势比1.48; 95% CI 0.44–5.00). A pooled study-level proportion of alteplase-associated mortality and sICH was 0.14 (95% CI 0.08–0.21) and 0.09 (95% CI 0.04–0.16), respectively. Compared with a mortality rate of 0.09 (95% CI 0.03–0.20) and an sICH rate of 0.07 (95% CI 0.02–0.17) in TNK-treated patients, no significant difference was observed.Discussion Functional outcomes, mortality, and sICH did not significantly differ between patients with TLs treated with TNK and those treated with alteplase.Classification of Evidence This study provides Class III evidence that TNK is associated with similar rates of intracranial reperfusion, functional outcome, mortality, and sICH compared with alteplase in patients with acute stroke due to TLs. However, the CIs do not rule out clinically important differences.Trial Registration Information clinicaltrials.gov/ct2/show/NCT02388061; clinicaltrials.gov/ct2/show/NCT03340493.CTA=CT angiography; DSA=digital subtraction angiography; eICA=extracranial internal carotid artery; eTICI=extended treatment in cerebral ischemia; LVO=large vessel occlusion; mRS=modified Rankin scale; NIHSS=NIH Stroke Scale; sICH=symptomatic intracranial hemorrhage; TL=tandem lesion; TNK=tenecteplase