TY -的T1 -在人口结构变化趋势,风险因素,感染患者的临床特征Endocarditis-Related中风,2005 - 2015年摩根富林明-神经学乔-神经病学SP - e1555 LP - - 10.1212 / WNL e1564做。半岛投注体育官网0000000000206865六世- 100 - 15 AU -穆罕默德Ridha盟-马修·l·费拉盟-优思明阿齐兹AU -埃兹劳拉盟凯萨琳Alwell AU -简·c·科盟-丹尼尔·吴盟-西蒙娜Ferioli AU - Opeolu Adeoye AU - Pooja Khatri AU -费利佩•德洛里奥斯La Rosa盟Eva a Mistry AU -斯泰西·l·Demel盟杰森·麦基AU - Sharyl马提尼盟Elisheva科尔曼AU -亚当Jasne盟盟Sabreena Slavin -凯尔·沃尔什AU -迈克尔星盟-玛丽Haverbusch AU -特雷西·e·马德森AU -约瑟夫·p·布罗德里克盟Brett Kissela AU - o .黎明Kleindorfer Y1 - 2023/04/11 UR - //www.ebmtp.com/content/100/15/e1555.abstract N2 -背景和目标有感染性endocarditis-related中风发病率的增高(IERS)承担在美国由于阿片类药物流行病。半岛投注体育官网有必要了解当代流行病学描述阿片类药物流行病的影响在日前发表的临床特征。我们描述和分析人口统计趋势,日前发表的危险因素和临床特征。方法这是一个回顾性队列研究中一个混血人口130万大辛辛那提/肯塔基州北部地区。出血性或缺血性中风患者住院都是识别和医生验证从2005年,2010年和2015年日历年使用ICD-9和icd - 10编码。日前被定义为急性中风归因于感染性心内膜炎会议修改杜克标准可能或明确的心内膜炎。未经调整的人口相比,风险因素,结果,临床特点是每个研究日前期限和non-IERS之间执行。调整后的模型比较趋势Cochran-Armitage测试用于分类变量和一般线性模型或克鲁斯卡尔-沃利斯检验数值变量。检查心内膜炎状态交互的趋势进行使用一般线性或物流模型。结果日前患者共有54和8204没有日前被确定在研究时期。 Between 2005 and 2015, there was a decline in rates of hypertension (91.7% vs 36.0%; p = 0.0005) and increased intravenous drug users (8.3% vs 44.0%; p = 0.02) in the IERS cohort. The remainder of the stroke population demonstrated a significant rise in hypertension, diabetes, atrial fibrillation, and perioperative stroke. Infective endocarditis status significantly interacted with the trend in hypertension prevalence (p = 0.001).Discussion From 2005 to 2015, IERS was increasingly associated with intravenous drug use and fewer risk factors, specifically hypertension. These trends likely reflect the demographics of the opioid epidemic, which has affected younger patients with fewer comorbidities.ICD-9=International Classification of Diseases–9; IERS9=infective endocarditis–related stroke; IQR=interquartile range; IVDU9=intravenous drug users; GCNKSS9=Greater Cincinnati Northern Kentucky Stroke Study; LKW=last known well; tPA9=tissue plasminogen activator ER -