抗癫痫药物三联疗法治疗胶质瘤合并难治性癫痫的疗效[j] - Neurology - SP - e1488 LP - e1496 DO - 10.1212/WNL.0000000000206852半岛投注体育官网六世- 100 - 14 AU - Pim b·范德梅尔盟琳达小说非盟-玛塔Fiocco盟Maaike j . Vos盟马蒂尔德蔡玫Kouwenhoven AU -马丁j . van den弯曲AU -马丁J.B. Taphoorn盟Johan自动跟踪Koekkoek Y1 - 2023/04/04 UR - //www.ebmtp.com/content/100/14/e1488.abstract N2 -背景和目标大约10%的神经胶质瘤患者癫痫需要抗癫半岛投注体育官网痫药物(ASM)三联疗法由于难治性癫痫。本研究的目的是评价左乙西坦联合丙戊酸氯巴唑(LEV + VPA + CLB)这一常用的三联疗法在胶质瘤患者中的疗效是否优于其他三联疗法。方法采用多中心回顾性观察队列研究。主要结局是从ASM三联治疗开始到任何原因导致治疗失败的累积时间发生率。次要结局包括以下累积发生率:(1)由于不受控制的癫痫发作导致治疗失败的时间;(2)因不良反应导致治疗失败的时间;(3)反复发作的时间。患者随访时间最长为36个月。在原始队列的1435例患者中，有90例患者在因癫痫发作失控而导致ASM二线治疗失败后接受了ASM三联疗法。48%(43/90)的患者采用LEV + VPA + CLB, 52%(47/90)的患者采用其他ASM三联疗法。 The cumulative incidence of treatment failure for any reason of LEV + VPA + CLB did not statistically significantly differ from that of other ASM triple therapy combinations (12 months: 47% [95% CI 31%–62%] vs 42% [95% CI 27%–56%], p = 0.892). No statistically significant differences for treatment failure due to uncontrolled seizures (12 months: 12% [95% CI 4%–25%] vs 18% [95% CI 8%–30%], p = 0.445), adverse effects (12 months: 22% [95% CI 11%–36%] vs 15% [95% CI 7%–27%], p = 0.446), or recurrent seizures (1 month: 65% [95% CI 48%–78%] vs 63% [95% CI 47%–75%], p = 0.911) were found.Discussion LEV + VPA + CLB might show equivalent effectiveness compared with other ASM triple therapy combinations in patients with glioma.Classification of Evidence This study provides Class III evidence that for patients with glioma with refractory epilepsy on triple therapy ASMs, LEV + VPA + CLB demonstrated similar effectiveness and tolerability compared with other ASM triple therapy combinations.ASM=antiseizure medication; BTRE=brain tumor–related epilepsy; CLB=clobazam; DDD=defined daily dosage; GABA=gamma aminobutyric acid; LCM=lacosamide; LEV=levetiracetam; PER=perampanel; VPA=valproic acid; WHO=World Health Organization ER -