TY -的T1 -孕前偏头痛,偏头痛表型和不良妊娠结局的风险JF -神经学乔-神经病学SP - e1464 LP - e1473做- 10.1212 / WNL。半岛投注体育官网0000000000206831六世- 100 - 14 AU -亚历山德拉·c·Purdue-Smithe盟詹妮弗·j·斯图尔特Jae h .康盟-莱斯利诉Farland盟盟-安德里亚·m·Harriott盟珍妮特·w·瑞奇爱德华盟——凯瑟琳Rexrode Y1 - 2023/04/04 UR - //www.ebmtp.com/content/100/14/e1464.abstract N2 -背景和客观的偏头痛是一种非常普遍的神经与血管的紊半岛投注体育官网乱生殖期的女性之一。偏头痛的历史和偏头痛表型是否作为临床产科风险的有用的标记不清楚。本研究的主要目的是检查协会孕前偏头痛和偏头痛表型与不良妊娠结局的风险。方法我们估计协会的自我报告被诊断出的偏头痛和偏头痛表型与不良妊娠结果未来的护士健康研究II (1989 - 2009)。Log-binomial log-Poisson模型和广义估计方程被用来估计相对风险(RRs)和95%独联体为妊娠期糖尿病(GDM)、子痫、妊娠高血压、早产和低出生体重。结果分析包括30555事件怀孕后群招生19694名参与者没有心血管疾病史,糖尿病或癌症。在调整了年龄、肥胖和其他健康和行为因素,孕前偏头痛(11%)与早产的风险更高(RR = 1.17;95% CI = 1.05 - -1.30)、妊娠高血压(RR = 1.28;95% CI = 1.11 - -1.48),和子痫前期(RR = 1.40;95% CI = 1.19 - -1.65)相比没有偏头痛。 Migraine was not associated with low birthweight (RR = 0.99; 95% CI = 0.85–1.16) or GDM (RR = 1.05; 95% CI = 0.91–1.22). Risk of preeclampsia was somewhat higher among participants with migraine with aura (RR vs no migraine = 1.51; 95% CI = 1.22–1.88) than migraine without aura (RR vs no migraine = 1.30; 95% CI = 1.04–1.61; p-heterogeneity = 0.32), whereas other outcomes were similar by migraine phenotype. Participants with migraine who reported regular prepregnancy aspirin use had lower risks of preterm delivery (<2×/week RR = 1.24; 95% CI = 1.11–1.38; ≥2×/week RR = 0.55; 95% CI = 0.35–0.86; p-interaction < 0.01) and preeclampsia (<2×/week RR = 1.48; 95% CI = 1.25–1.75; ≥2×/week RR = 1.10; 95% CI = 0.62–1.96; p-interaction = 0.39); however, power for these stratified analyses was limited.Discussion Migraine history, and to a lesser extent migraine phenotype, appear to be important considerations in obstetric risk assessment and management. Future research should determine whether aspirin prophylaxis may be beneficial for preventing adverse pregnancy outcomes among pregnant individuals with a history of migraine.BMI=body mass index; GDM=gestational diabetes mellitus; HDP=hypertensive disorders in pregnancy; ICHD-II=International Classification of Headache Disorders-II; MET=metabolic equivalent of task; NHSII=Nurses' Health Study II; RR=relative risks ER -