@article {Purdue-Smithee1464，作者= {Alexandra C. Purdue-Smithe, Jennifer J. Stuart, Leslie V. Farland, Jae H. Kang, Andrea M. Harriott, Janet W. Rich-Edwards和Kathryn Rexrode}，标题={孕前偏头痛，偏头痛表型和不良妊娠结局的风险}，卷={100}，数={14}，页= {e1464—e1473}，年= {2023}，doi = {10.1212/WNL。0000000000206831}，出版商= {Wolters Kluwer Health, Inc.代表美国神经病学学会}，摘要={背景和目的偏头痛是育龄妇女中非常普遍的神经血管疾病。半岛投注体育官网偏头痛病史和偏头痛表型是否可以作为产科风险的临床有用标记尚不清楚。本研究的主要目的是检查孕前偏头痛和偏头痛表型与不良妊娠结局风险的关系。方法:在前瞻性护士健康研究II(1989年)中，我们估计了自我报告的医生诊断的偏头痛和偏头痛表型与不良妊娠结局的关联。采用广义估计方程的log-二项和log-泊松模型来估计妊娠糖尿病(GDM)、子痫前期、妊娠高血压、早产和低出生体重的相对危险度(rr)和95% ci。结果:在19694名没有心血管疾病、糖尿病或癌症病史的参与者中，分析包括30555名意外怀孕。在调整了年龄、肥胖和其他健康和行为因素后，孕前偏头痛(11%)与早产的高风险相关(RR = 1.17;95% CI = 1.05{\textendash}1.30)，妊娠期高血压(RR = 1.28;95% CI = 1.11{\textendash}1.48)，子痫前期(RR = 1.40;95% CI = 1.19{\textendash}1.65)。偏头痛与低出生体重无关(RR = 0.99; 95\% CI = 0.85{\textendash}1.16) or GDM (RR = 1.05; 95\% CI = 0.91{\textendash}1.22). Risk of preeclampsia was somewhat higher among participants with migraine with aura (RR vs no migraine = 1.51; 95\% CI = 1.22{\textendash}1.88) than migraine without aura (RR vs no migraine = 1.30; 95\% CI = 1.04{\textendash}1.61; p-heterogeneity = 0.32), whereas other outcomes were similar by migraine phenotype. Participants with migraine who reported regular prepregnancy aspirin use had lower risks of preterm delivery (\<2{\texttimes}/week RR = 1.24; 95\% CI = 1.11{\textendash}1.38; >=2{\texttimes}/week RR = 0.55; 95\% CI = 0.35{\textendash}0.86; p-interaction \< 0.01) and preeclampsia (\<2{\texttimes}/week RR = 1.48; 95\% CI = 1.25{\textendash}1.75; >=2{\texttimes}/week RR = 1.10; 95\% CI = 0.62{\textendash}1.96; p-interaction = 0.39); however, power for these stratified analyses was limited.Discussion Migraine history, and to a lesser extent migraine phenotype, appear to be important considerations in obstetric risk assessment and management. Future research should determine whether aspirin prophylaxis may be beneficial for preventing adverse pregnancy outcomes among pregnant individuals with a history of migraine.BMI=body mass index; GDM=gestational diabetes mellitus; HDP=hypertensive disorders in pregnancy; ICHD-II=International Classification of Headache Disorders-II; MET=metabolic equivalent of task; NHSII=Nurses{\textquoteright} Health Study II; RR=relative risks}, issn = {0028-3878}, URL = {//www.ebmtp.com/content/100/14/e1464}, eprint = {//www.ebmtp.com/content/100/14/e1464.full.pdf}, journal = {Neurology} }