PT -期刊文章盟拉希德·艾哈迈德AU -卡尔Mhina盟卡兰菲利普AU - Smit d . Patel盟Ehimen Aneni AU - Chukwuemeka Osondu盟Oluwatomi Lamikanra AU - Emmanuel Oladele,非盟赤野光信案件Nnabuchi Anikpezie盟——卡伦·c·奥尔布赖特AU -朱利叶斯·g·Latorre盟Seemant查图尔维迪盟Fadar奥利弗Otite TI -年龄和性别趋势在急性缺血性中风后并发症- 10.1212 / WNL.0000000000206749在美国援助DP - 2023 3月21日TA - Ne半岛投注体育官网urology PG - e1282—e1295 VI - 100 IP - 12 4099 - //www.ebmtp.com/content/100/12/e1282.short 4100 - //www.ebmtp.com/content/100/12/e1282.full SO - Neurology2023 3月21日;背景和目的验证2007 - 2019年美国急性缺血性卒中(AIS)住院后感染性(肺炎、败血症和尿路感染[UTI])和非感染性(深静脉血栓形成[DVT]、肺栓塞[PE]、急性肾功能衰竭[ARF]、急性心肌梗死[AMI]和胃肠道出血[GIB])并发症的年龄和性别特异性患病率增加的假设。方法:我们使用2007-2019年全国住院患者样本进行了一系列横断面研究。使用国际疾病分类代码确定有或无并发症的成人(18岁或以上)原发性AIS入院。我们量化了并发症的年龄/性别特异性患病率，并使用负二项回归模型来评估随时间变化的趋势。结果5751,601名加权入院患者中，51.4%为女性。25.1%至少有1种并发症。UTI(11.8%)、ARF(10.1%)、肺炎(3.2%)和AMI(2.5%)是最常见的并发症，而脓毒症(1.7%)、GIB(1.1%)、DVT(1.2%)和PE(0.5%)是最不常见的并发症。不同年龄/性别的并发症风险存在显著差异(UTI:男性18-39岁2.1%;80岁以上妇女22.5%)。2007-2019年期间，尿路感染(12.9%-9.7%)和肺炎(3.8%-2.7%)的患病率下降，但ARF的患病率增加了约3倍(4.8%-14%)(p < 0.001). AMI (1.9%–3.1%), DVT (1.0%–1.4%), and PE (0.3%–0.8%) prevalence also increased (p < 0.001), but that of sepsis and GIB remained unchanged over time. After multivariable adjustment, risk of all complications increased with increasing NIH Stroke Scale (pneumonia: prevalence rate ratio [PRR] 1.03, 95% CI 1.03–1.04, for each unit increase), but IV thrombolysis was associated with a reduced risk of all complications (pneumonia: PRR 0.80, 85% CI 0.73–0.88; AMI: PRR 0.85, 95% CI 0.78–0.92; and DVT PRR 0.87, 95% CI 0.78–0.98). Mechanical thrombectomy was associated with a reduced risk of UTI, sepsis, and ARF, but DVT and PE were more prevalent in MT hospitalizations compared with those without. All complications except UTI were associated with an increased risk of in-hospital mortality (sepsis: PRR 1.97, 95% CI 1.78–2.19).Discussion Infectious complications declined, but noninfectious complications increased after AIS admissions in the United States in the last decade. Utilization of IV thrombolysis is associated with a reduced risk of all complications.AIS=acute ischemic stroke; AMI=acute myocardial infarction; ARF=acute renal failure; CKD=chronic kidney disease; DVT=deep venous thrombosis; GIB=gastrointestinal bleeding; HCUP=Healthcare Cost and Utilization Project; ICD-9=International Classification of Diseases, 9th Revision; ICD-10=International Classification of Diseases, 10th Revision; ICH=intracerebral hemorrhage; MT=mechanical thrombectomy; MV=mechanically ventilated; NIHSS=NIH Stroke Scale; NIS=Nationwide Inpatient Sample; PE=pulmonary embolism; PRR=prevalence rate ratio; UTI=urinary tract infection

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