TY -的T1 -编者注:饮食习惯之间的关系在20年内中年与老年痴呆发病率的JF -神经学乔-神经病学SP - 593 LP - 593 - 10.1212 / WNL。半岛投注体育官网0000000000207162六世- 100 - 12盟Aravind Ganesh AU -史蒂文Galetta Y1 - 2023/03/21 UR - //www.ebmtp.com/c半岛投注体育官网ontent/100/12/593.1.abstract N2 - 2-decade潜在人群为基础的研究来自瑞典,龟头博士和他的同事们调查之间的关系坚持传统的饮食建议或者修改地中海饮食和后续发展中全因痴呆的风险,阿尔茨海默病(AD)、血管性痴呆(VaD),或积累AD-relatedβ-amyloid病理学CSF, 28025名参与者。他们得出结论,这些饮食习惯没有显著与发展中全因老年痴呆症的风险降低有关,AD痴呆,VaD、AD病理。作为回应,博士Kawada援引的一项研究发现重要的饮食模式之间的相互作用和APOE-ε4痴呆状态与事件,一个健康的饮食模式是降低痴呆发病率在ε4非携带者和西方饮食模式与ε4运营商痴呆发病率高有关。Kawada博士认为,研究饮食模式的长期影响事件痴呆应该考虑遗传因素的贡献。在另一个反应,霍夫曼博士指出,研究人员使用一种修改地中海饮食得分没有明确措施特级初榨橄榄油(EVOO),这可能是一个重要的组件来保持健康的认知能力,以流行病学和动物研究在这方面。他认为,重要的是考虑的角色EVOO作为地中海饮食的一部分,对认知的健康更好的通知在non-Mediterranean国家这个饮食的实现。应对这些评论,作者指出,他们没有发现任何显著的交互作用之间的传统饮食建议或修改后的地中海饮食和APOE-ε4状态对后续痴呆但不要评论特级初榨橄榄油的作用。总的来说,这交易突显出持久的不确定性的作用具体饮食因素在降低痴呆的长期风险。2-decade潜在人群为基础的研究从瑞典,龟头博士和他的同事们调查之间的关系坚持传统膳食的建议或者修改地中海饮食和后续发展中全因痴呆的风险,阿尔茨海默病(AD)、血管性痴呆(VaD),或积累AD-relatedβ-amyloid病理学CSF, 28025名参与者。 They concluded that these dietary habits were not significantly associated with a reduced risk for developing all-cause dementia, AD dementia, VaD, or AD pathology. In response, Dr. Kawada cites a previous study that found significant interactions between dietary patterns and APOE-ε4 status in relation to incident dementia, with a healthy dietary pattern being associated with lower dementia incidence in ε4 noncarriers and a Western dietary pattern associated with higher dementia incidence in ε4 carriers. Dr. Kawada argues that studies examining the long-term effect of dietary patterns on incident dementia should consider the contribution of genetic factors. In another response, Dr. Hoffman notes that the researchers' use of a modified Mediterranean diet score does not explicitly measure for extra virgin olive oil (EVOO), which may be an important component for maintaining cognitive health, citing epidemiologic and animal studies in this regard. He contends that it is important to consider the role of EVOO as part of a Mediterranean diet for cognitive health to better inform the implementation of this diet in non-Mediterranean countries. Responding to these comments, the authors note that they did not find any significant interaction effects between conventional dietary recommendations or a modified Mediterranean diet and APOE-ε4 status with respect to subsequent dementia but do not comment about the role of extra virgin olive oil. Overall, this exchange highlights enduring uncertainties about the role of specific dietary factors in mitigating the long-term risk of dementia. ER -