TY - T1的抑郁症状和急性中风的风险:INTERSTROKE病例对照研究摩根富林明-神经学乔-神经- 10.1212 / WNL。半岛投注体育官网0000000000207093 SP - 10.1212 / WNL。0000000000207093 AU -墨菲,罗伯特•P AU - Reddin娜AU -罗森格林,安妮卡盟——法官,康纳盟,纸巾,格雷姆j . AU -弗格森,约翰•AU - Alvarez-Iglesias Alberto盟——Oveisgharan Shahram AU - Wasay,默罕默德盟-麦克德莫特,Clodagh盟——球队,赫勒克林根贝格AU -拉娜,费尔南多盟——AL-HUSSAIN FAWAZ AU - Czlonkowska安娜盟——它Aytekin盟——Ogunniyi Adesola盟——Damasceno Albertino AU -泽维尔,丹尼斯AU - Avezum,阿尔瓦罗·王盟——Xingyu盟——蓝鸿恩彼得盟——优素福,萨利姆AU - O ' donnell,马丁•AU - Y1 - 2023/03/08 UR - //www.ebmtp.com/content/early/2023/03/08/WNL.0000000000207093.abstract N2 -背景和ObjectivesDepression报道急性中风的一个危险因素,主要基于研究在高收入国家。半岛投注体育官网INTERSTROKE的研究中,我们探讨抑郁症状急性中风风险的贡献,个月结果世界各地区,在亚种群和中风typeMethodsINTERSTROKE是国际第一急性中风的危险因素的病例对照研究,在32个国家进行的。例患者CT或MRI证实事件急性中风住院,匹配和控制了年龄,性别,和在网站。标准化问题问及自我抑郁症状在过去12个月,使用规定的抗抑郁药物都被记录下来。多变量条件逻辑回归是用来确定协会pre-stroke抑郁症状与急性中风的风险。调整顺序逻辑回归被用来探索协会pre-stroke抑郁症状与中风后功能结果,测量modified-Rankin量表在中风后个月。ResultsOf 26877参与者中,40.4%是女性,平均年龄为61.7±13.4年。抑郁症状的发病率在过去的12个月相比较高的情况下控制(vs.14.1% 18.3%, p & lt;0.001)和不同地区(pinteraction & lt;0.001),与中国在控制(6.9%)的患病率最低和最高在南美洲(控制)的32.2%。 In multivariable analyses pre-stroke depressive symptoms were associated with greater odds of acute stroke (OR 1.46, 95%CI 1.34–1.58), which was significant for both intracerebral hemorrhage (OR 1.56, 95%CI 1.28–1.91) and ischemic stroke (OR 1.44, 95%CI 1.31–1.58). A larger magnitude of association with stroke was seen in patients with a greater burden of depressive symptoms. While pre-admission depressive symptoms were not associated with a greater odds of worse baseline stroke severity (OR 1.02, 95%CI 0.94–1.10), they were associated with a greater odds of poor functional outcome at 1-month after acute stroke (OR 1.09, 95%CI 1.01–1.19).DiscussionIn this global study we recorded that depressive symptoms are an important risk factor for acute stroke, including both ischemic and hemorrhagic stroke. Pre-admission depressive symptoms were associated with poorer functional outcome, but not baseline stroke severity, suggesting an adverse role of depressive symptoms in post-stroke recovery. ER -