杂志文章%A墨菲，罗伯特·雷丁，卡特里奥娜·罗森格伦，安妮卡法官，康纳·汉基，格雷姆·弗格森，约翰·阿尔瓦雷斯-伊格莱西亚斯，阿尔贝托·奥韦伊斯哈兰，沙赫拉姆·瓦塞，穆罕默德·麦克德莫特，克罗达·艾弗森，赫勒·克林根贝格·拉纳斯，费尔南多·侯赛因，法瓦兹·Czlonkowska，安娜·奥古兹，阿伊特金·奥古尼伊，阿德索拉·Damasceno，阿尔伯蒂诺·沙维尔，丹尼斯·阿韦祖姆，阿尔瓦罗·王，兴宇·朗霍恩，彼得·尤瑟夫，萨利姆·奥唐奈，马丁，抑郁症状与急性脑卒中风险:脑卒中间期病例对照研究%D 2023 %R 10.1212/WNL。0000000000207093神经病学半岛投注体育官网%P 10.1212/WNL。背景和目的抑郁症已被报道为急性中风的危险因素，这主要基于高收入国家的研究。在INTERSTROKE研究中，我们探讨了抑郁症状对急性卒中风险和1个月预后的影响，包括世界各地区、亚人群和卒中类型。病例为CT或MRI确诊的急性住院卒中患者，对照组根据年龄、性别和部位进行匹配。标准化问题被问及过去12个月内自我报告的抑郁症状，并记录了处方抗抑郁药物的使用情况。多变量条件logistic回归用于确定卒中前抑郁症状与急性卒中风险的相关性。采用调整后的有序logistic回归探讨卒中前抑郁症状与卒中后功能结局的相关性，并在卒中后1个月用改良rankin量表进行测量。结果26877例患者中女性占40.4%，平均年龄61.7±13.4岁。与对照组相比，病例在过去12个月内抑郁症状的患病率较高(18.3%vs.14.1%，p < 0.001)，并因地区而异(p交互作用< 0.001)，中国患病率最低(对照组为6.9%)，南美洲患病率最高(对照组为32.2%)。在多变量分析中，卒中前抑郁症状与更大的急性卒中发生率相关(OR 1.46, 95%CI 1.34-1.58)，这对脑出血(OR 1.56, 95%CI 1.28-1.91)和缺血性卒中(OR 1.44, 95%CI 1.31-1.58)均显著。 A larger magnitude of association with stroke was seen in patients with a greater burden of depressive symptoms. While pre-admission depressive symptoms were not associated with a greater odds of worse baseline stroke severity (OR 1.02, 95%CI 0.94–1.10), they were associated with a greater odds of poor functional outcome at 1-month after acute stroke (OR 1.09, 95%CI 1.01–1.19).DiscussionIn this global study we recorded that depressive symptoms are an important risk factor for acute stroke, including both ischemic and hemorrhagic stroke. Pre-admission depressive symptoms were associated with poorer functional outcome, but not baseline stroke severity, suggesting an adverse role of depressive symptoms in post-stroke recovery. %U //www.ebmtp.com/content/neurology/early/2023/03/08/WNL.0000000000207093.full.pdf