@article {Murphy10.1212 / WNL。0000000000207093,作者={墨菲,罗伯特•P和Reddin娜和工厂的安妮卡和法官,康纳和纸巾,格雷姆·j·弗格森,约翰和Alvarez-Iglesias阿尔贝托和Oveisgharan Shahram Wasay,默罕默德·麦克德莫特,Clodagh和球队,克林根贝格赫勒和拉娜,费尔南多和AL-HUSSAIN FAWAZ Czlonkowska,安娜和它,Aytekin Ogunniyi, Adesola Damasceno, Albertino和泽维尔,丹尼斯和Avezum,阿尔瓦罗·王,Xingyu蓝鸿恩,彼得和优素福萨利姆和O {\ textquoteright} Donnell,马丁,},title ={抑郁症状和急性中风的风险:INTERSTROKE病例对照研究},elocation-id = {10.1212 / WNL。={2023}0000000000207093},年,doi = {10.1212 / WNL。出版商0000000000207093}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景和ObjectivesDepression报道急性中风的一个危险因素,主要半岛投注体育官网基于研究在高收入国家。INTERSTROKE的研究中,我们探讨抑郁症状急性中风风险的贡献,个月结果世界各地区,在亚种群和中风typeMethodsINTERSTROKE是国际第一急性中风的危险因素的病例对照研究,在32个国家进行的。例患者CT或MRI证实事件急性中风住院,匹配和控制了年龄,性别,和在网站。标准化问题问及自我抑郁症状在过去12个月,使用规定的抗抑郁药物都被记录下来。多变量条件逻辑回归是用来确定协会pre-stroke抑郁症状与急性中风的风险。调整顺序逻辑回归被用来探索协会pre-stroke抑郁症状与中风后功能结果,测量modified-Rankin量表在中风后个月。ResultsOf 26877参与者,40.4 \ %是女性,平均年龄为61.7 {\ textpm} 13.4年。抑郁症状的发病率在过去的12个月相比,较高的情况下控制(18.3 \ % vs.14.1 \ % p \ < 0.001),不同地区(pinteraction \ < 0.001),与中国患病率最低(6.9 \ %的控制),在南美洲最高(32.2 \ %的控制)。在多变量分析pre-stroke抑郁症状与急性中风的几率较高(1.34或1.46,95 \ % CI {\ textendash} 1.58),这是重要的对于脑出血(1.28或1.56,95 \ % CI {\ textendash} 1.91)和缺血性中风(1.31或1.44,95 \ % CI {\ textendash} 1.58)。 A larger magnitude of association with stroke was seen in patients with a greater burden of depressive symptoms. While pre-admission depressive symptoms were not associated with a greater odds of worse baseline stroke severity (OR 1.02, 95\%CI 0.94{\textendash}1.10), they were associated with a greater odds of poor functional outcome at 1-month after acute stroke (OR 1.09, 95\%CI 1.01{\textendash}1.19).DiscussionIn this global study we recorded that depressive symptoms are an important risk factor for acute stroke, including both ischemic and hemorrhagic stroke. Pre-admission depressive symptoms were associated with poorer functional outcome, but not baseline stroke severity, suggesting an adverse role of depressive symptoms in post-stroke recovery.}, issn = {0028-3878}, URL = {//www.ebmtp.com/content/early/2023/03/08/WNL.0000000000207093}, eprint = {//www.ebmtp.com/content/early/2023/03/08/WNL.0000000000207093.full.pdf}, journal = {Neurology} }