RT杂志文章SR电子T1诱导爆发抑制与顽固性癫痫持续状态患者临床结果的相关性:一项9年队列研究半岛投注体育官网10.1212 / WNL.0000000000207129A1 Fisch, Urs A1 Jünger, Anja L. A1 Baumann, Sira M A1 Semmlack, Saskia A1 De Marchis, Gian Marco A1 Hunziker, Sabina A1 RüeggFAES, Stephan A1 Marsch, Stephan A1 Sutter, Raoul YR 2023 UL http://n.半岛投注体育官网neurology.org/content/early/2023/03/08/WNL.0000000000207129.abstract AB目的探讨成人难治性癫痫持续状态(RSE)患者在持续静脉麻醉(IVAD)期间诱发脑电图(EEG)爆发抑制模式的频率及相关结局。方法:纳入2011-2019年在瑞士学术护理中心接受麻醉药治疗的RSE患者。评估临床资料和半定量脑电图分析。抑爆分为不完全抑爆(抑制比例≥20%,<50%)和完全抑爆(抑制比例≥50%)。诱发发作抑制的频率以及发作抑制与结局(持续发作终止、住院生存率和恢复发病前神经功能)的相关性为终点。结果:我们确定了147例接受IVAD治疗的RSE患者。在102例无脑缺氧患者中,14例(14%)实现了不完全爆发抑制,中位时间为23小时(四分位范围[IQR] 1-29), 21例(21%)实现了完全爆发抑制,中位时间为51小时(IQR 16-104)。年龄、Charlson共病指数、伴有运动症状的RSE和癫痫持续状态严重程度评分(stress)被认为是在有和没有任何爆发抑制的患者之间进行单变量比较的潜在混杂因素。多变量分析显示任何抑制爆发与预定义终点之间没有关联。 However, among 45 patients with cerebral anoxia, induced burst-suppression was associated with persistent seizure termination (72% without vs. 29% with burst-suppression, p=0.004) and survival (50% vs. 14% p=0.005).Conclusions: In adult patients with RSE treated with IVAD, burst-suppression with ≥50% suppression proportion was achieved in every fifth patient and not associated with persistent seizure termination, in-hospital survival or return to premorbid neurologic function.
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