TY - JOUR T1 -晚期脑年龄和慢性卒中后失语严重程度JF -神经学JO -神经学SP - e1166 LP - e1176 DO - 10.1212半岛投注体育官网/WNL.0000000000201693VL - 100 IS - 11 AU - Busby, Natalie AU - Wilmskoetter, Janina AU - Gleichgerrcht, Ezequiel AU - Rorden, Chris AU - Roth, Rebecca AU - Newman-Norlund, Roger AU - Hillis, Argye Elizabeth AU - Keller, Simon S. AU - de Bezenac, Christophe AU - Kristinsson, Sigfus AU - Fridriksson, Julius AU - Bonilha，Leonardo Y1 - 2023/03/14 UR - http://n.半岛投注体育官网neurology.org/content/100/11/e1166.abstract N2 -背景和目标慢性脑卒中后语言障碍通常在老年人或脑卒中病变较大的人群中更严重。然而，存在不明原因的差异，可能取决于病变以外的完整组织。脑年龄是一个新兴的概念，它部分地独立于实际年龄。大脑老化与健康老年人的认知能力下降有关;因此，我们旨在探讨卒中失语症与卒中失语症的关系。我们假设，脑老化是与慢性脑卒中后语言障碍相关的重要因素，超过了年龄和病变特征。这项队列研究回顾性评估了失语症语言康复预测结果临床试验(NCT03416738)的参与者，这些参与者是通过美国南卡罗来纳州的当地广告招募的。主要纳入标准为左半球卒中和慢性失语(卒中后≥12个月)。 Participants completed baseline behavioral testing including the Western Aphasia Battery–Revised (WAB-R), Philadelphia Naming Test (PNT), Pyramids and Palm Trees Test (PPTT), and Wechsler Adult Intelligence Scale Matrices subtest, before completing 6 weeks of language therapy. The PNT was repeated 1 month after therapy. We leveraged modern neuroimaging techniques to estimate brain age and computed a proportional difference between chronologic age and estimated brain age. Multiple linear regression models were used to evaluate the relationship between proportional brain age difference (PBAD) and behavior.Results Participants (N = 93, 58 males and 35 females, average age = 61 years) had estimated brain ages ranging from 14 years younger to 23 years older than chronologic age. Advanced brain age predicted performance on semantic tasks (PPTT) and language tasks (WAB-R). For participants with advanced brain aging (n = 47), treatment gains (improvement on the PNT) were independently predicted by PBAD (T = −2.0474, p = 0.0468, 9% of variance explained).Discussion Through the application of modern neuroimaging techniques, advanced brain aging was associated with aphasia severity and performance on semantic tasks. Notably, therapy outcome scores were also associated with PBAD, albeit only among participants with advanced brain aging. These findings corroborate the importance of brain age as a determinant of poststroke recovery and underscore the importance of personalized health factors in determining recovery trajectories, which should be considered during the planning or implementation of therapeutic interventions.TE=echo time; TI=inversion time; PBAD=proportional brain age difference; PNT=Philadelphia Naming Test; PPTT=Pyramids and Palm Trees Test; POLAR=Predicting Outcomes of Language Rehabilitation in Aphasia; TR=repetition time; WAB-AQ=Western Aphasia Battery–Aphasia Quotient; WAB-R=Western Aphasia Battery–Revised; WAIS=Wechsler Adult Intelligence Scale ER -