% 0期刊文章%巴斯比,娜塔莉% Wilmskoetter,怪不得我% Gleichgerrcht, Ezequiel % Rorden,克里斯%罗斯,瑞贝卡% Newman-Norlund,罗杰% Hillis, Argye伊丽莎白%凯勒,西蒙•s % de Bezenac克利斯朵夫% Kristinsson, Sigfus % Fridriksson,朱利叶斯% Bonilha,莱昂纳多% T先进的大脑年龄和慢性卒中后失语严重程度% D R 10.1212 / WNL 2023%。0000000000201693 % J半岛投注体育官网神经病学% P e1166-e1176 % V 100% N 11% X背景和目标慢性卒中后语言障碍通常是更糟的是老年人和那些有大量中风病灶。然而,有无法解释的方差,可能取决于完整组织以外的病变。脑年龄是一个新兴的概念,这是部分独立于时间年龄。先进的大脑年龄与健康老年人认知能力的下降;因此,我们的目的是探讨与中风失语症的关系。我们假设先进的大脑年龄是一个重要因素与慢性卒中后语言障碍,超越时间年龄、病变特征。方法回顾性队列研究评估参与者从语言康复治疗失语症的临床试验的预测结果(NCT03416738),通过当地招募广告在南卡罗来纳(美国)。主要包括标准是左半球中风和慢性失语症(≥12个月后中风)。参与者完成了基线行为测试包括西方失语症Battery-Revised (WAB-R),费城命名测试(PNT)、金字塔和棕榈树测试(PPTT)和韦氏成人智力量表矩阵分测验,在完成6周的语言治疗。PNT是重复治疗后1个月。 We leveraged modern neuroimaging techniques to estimate brain age and computed a proportional difference between chronologic age and estimated brain age. Multiple linear regression models were used to evaluate the relationship between proportional brain age difference (PBAD) and behavior.Results Participants (N = 93, 58 males and 35 females, average age = 61 years) had estimated brain ages ranging from 14 years younger to 23 years older than chronologic age. Advanced brain age predicted performance on semantic tasks (PPTT) and language tasks (WAB-R). For participants with advanced brain aging (n = 47), treatment gains (improvement on the PNT) were independently predicted by PBAD (T = −2.0474, p = 0.0468, 9% of variance explained).Discussion Through the application of modern neuroimaging techniques, advanced brain aging was associated with aphasia severity and performance on semantic tasks. Notably, therapy outcome scores were also associated with PBAD, albeit only among participants with advanced brain aging. These findings corroborate the importance of brain age as a determinant of poststroke recovery and underscore the importance of personalized health factors in determining recovery trajectories, which should be considered during the planning or implementation of therapeutic interventions.TE=echo time; TI=inversion time; PBAD=proportional brain age difference; PNT=Philadelphia Naming Test; PPTT=Pyramids and Palm Trees Test; POLAR=Predicting Outcomes of Language Rehabilitation in Aphasia; TR=repetition time; WAB-AQ=Western Aphasia Battery–Aphasia Quotient; WAB-R=Western Aphasia Battery–Revised; WAIS=Wechsler Adult Intelligence Scale %U //www.ebmtp.com/content/neurology/100/11/e1166.full.pdf