TY - JOUR T1 -新近诊断局灶性癫痫患者的情绪、焦虑障碍和自杀倾向JF -神经学JO -神经学SP - e1123 LP - e1134 DO - 10.1212/WNL.0000000000201671半岛投注体育官网六世- 100 - 11盟Kanner Andres m . AU - Saporta Anita s . AU -金董h . AU -巴里,约翰·j . AU - Altalib岩漠AU - Omotola,希望非盟- Jette娜塔莉AU -奥布莱恩,特伦斯j . AU -纳卡尼,悉达多盟,Winawer旋律r . AU -斯珀林,迈克尔盟——法国,杰奎琳·a . AU - Abou-Khalil巴塞尔因车祸AU - Alldredge,布莱恩盟——Bebin玛蒂娜AU - Cascino,格雷戈里·d . AU -科尔,安德鲁j . AU -库克,Mark j . AU - Detyniecki卡米尔盟——Devinsky奥林盟——Dlugos丹尼斯盟——Faught爱德华AU -菲克,大卫盟——字段,玛德琳盟——Gidal巴里AU -盖尔芬德(Michael AU -格林,西蒙AU -哈尔福德,乔纳森•j . AU -上流社会的谢丽尔盟——对冲基金,马努盟——福尔摩斯Manisha g . AU - Kalviainen Reetta AU -康,在俊AU -克莱恩,帕维尔AU -伟达,罗伯特·c·AU -萨•Kaarkuzhali盟——Kuzniecky鲁本盟——关颖珊,帕特里克AU -洛温斯坦,Daniel h . AU -马尔库塞,劳拉盟——tommeador一路Kimford j . AU -明茨,斯科特•AU - Pardoe希思r . AU -公园,克里斯汀盟——PenovichPatricia AU - Singh, Rani K. AU - Somerville, Ernest AU - Szabo, Charles A. AU - Szaflarski, Jerzy P. AU - Lin Thio, K. Liu AU - Trinka, Eugen AU - Burneo, Jorge G. AU -, Y1 - 2023/03/14 UR - http://n.n半岛投注体育官网eurology.org/content/100/11/e1123.abstract N2 -背景和目标癫痫患者的情绪、焦虑障碍和自杀倾向比普通人群更常见。然而,在癫痫诊断时,与自杀倾向相关的情绪和焦虑障碍的患病率和类型尚未确定。我们试图在新诊断的局灶性癫痫患者中回答这些问题,并评估他们与自杀意念和企图的关系。方法数据来源于人类癫痫项目研究。共有347名18-60岁的连续成年人在开始治疗4个月内被新诊断为局灶性癫痫。情绪障碍和焦虑症的类型是通过小型国际神经精神病学访谈确定的,而自杀意念(一生,当前,主动和被动)和自杀企图(一生和当前)是通过哥伦比亚自杀严重程度评定量表(CSSRS)确定的。统计学分析包括t检验、χ2统计和logistic回归分析。结果151例(43.5%)患者有精神病诊断;134人(38.6%)符合情绪和/或焦虑障碍的标准,75人(21.6%)报告有或没有自杀企图。 Mood (23.6%) and anxiety (27.4%) disorders had comparable prevalence rates, whereas both disorders occurred together in 43 patients (12.4%). Major depressive disorders (MDDs) had a slightly higher prevalence than bipolar disorders (BPDs) (9.5% vs 6.9%, respectively). Explanatory variables of suicidality included MDD, BPD, panic disorders, and agoraphobia, with BPD and panic disorders being the strongest variables, particularly for active suicidal ideation and suicidal attempts.Discussion In patients with newly diagnosed focal epilepsy, the prevalence of mood, anxiety disorders, and suicidality is higher than in the general population and comparable to those of patients with established epilepsy. Their recognition at the time of the initial epilepsy evaluation is of the essence.ASM=antiseizure medication; BPD=bipolar disorder; CSSRS=Columbia Suicidality Severity Rating Scale; MDD=major depressive disorder; MDE=major depressive episode; MINI=the Mini International Neuropsychiatric Interview; SA=suicidal attempt; SI=suicidal ideation; PWE=people with epilepsy ER -
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