@article {Leee1148作者={萨拉·李和迈克尔Mlynash Soren克里斯腾森和江本马克斯Wintermark和罗纳德·Str和Gabriel Broocks{\“}和阿斯特丽德克Omid Nikoubashman和安德里亚Morotti Johannes Trenkler和马库斯·M {\ " o} hlenbruch和Jens Fiehler莫里茨Wildgruber和安德烈Kemmling腻过Psychogios和彼得·b·斯波恩}标题= {Hyperacute灌注成像在儿科血栓切除术},体积={100}={11},页面= {e1148——e1158} = {2023}, doi = {10.1212 / WNL。出版商0000000000201687}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景和目标灌注成像能够识别成人脑组织可抢救的患者将受益于血栓切除术在以后的时间半岛投注体育官网窗口。获得hyperacute灌注的可行性序列在儿科中风是未知的。本研究的目的是确定是否对比灌注成像延迟时间治疗和评估灌注概要文件在儿童大血管闭塞中风。方法拯救孩子的回顾性队列研究(2018年12月2000年1月{\ textendash})入学的孩子(1月{\ textendash} 18年)与中风从27个欧洲和美国接受血栓切除术中风中心。这二次分析包括前循环阻塞的患者,可用神经影像成像直接审查的核心实验室。群体间的比较进行了使用Wilcoxon rank-sum精确测试连续变量或Fisher精确检验二进制变量。考虑到患者,灌注成像评价参数进行描述性的。结果可用的33名患者神经影像,15(45.4 \ %)进行灌注(CT灌注n = 6;MR灌注n = 9);在技术上都足够了。中位数时间从发病到血管再通组没有差异{4小时(四分位范围(差)4 {\ textendash} 7.5)灌注+; 3.4 hours (IQR 2.5{\textendash}6.5) perfusion-, p = 0.158}. Target mismatch criteria were met by 10/15 (66.7\%) patients and did not correlate with reperfusion status or functional outcome. The hypoperfusion intensity ratio (HIR) was favorable in 11/15 patients and correlated with older age but not NIHSS, time to recanalization, or stroke etiology. Favorable HIR was associated with better functional outcome at 6 months (Pediatric Stroke Outcome Measure 1.0 [IQR 0.5{\textendash}2.0] vs 2.0 [1.5{\textendash}3.0], p = 0.026) and modified Rankin Scale 1.0 [0{\textendash}1] vs 2.0 [1.5{\textendash}3.5], p = 0.048) in this small sample.Discussion Automated perfusion imaging is feasible to obtain acutely in children and does not delay time to recanalization. Larger prospective studies are needed to determine biomarkers of favorable outcome in pediatric ischemic stroke and to establish core and penumbral thresholds in children.ADC=apparent diffusion coefficient; CASCADE=Childhood Arterial Ischemic Stroke Standardized Classification and Diagnostic Evaluation; DWI=diffusion-weighted imaging; HIR=hypoperfusion intensity ratio; IV=intravenous; IQR=interquartile range; LKW=last known well; LVO=large vessel occlusion; mRS=modified Rankin Scale; mTICI=modified Treatment in Cerebral Infarction; pNIHSS=pediatric National Institutes of Health Stroke Scale; PSOM=Pediatric Stroke Outcome Measure; ROC=receiver-operating characteristic; rCBF=relative cerebral blood flow; Tmax=time to maximum tissue residue function; TMM=Target Mismatch}, issn = {0028-3878}, URL = {//www.ebmtp.com/content/100/11/e1148}, eprint = {//www.ebmtp.com/content/100/11/e1148.full.pdf}, journal = {Neurology} }