PT -期刊文章盟杨Wookjin盟——荣格,Keun-Hwa AU -康,东莞盟-李,Eung-Joon盟——宋Han-Yeong AU - Chung,马修AU -金,Youngjoon盟——哈,Jiyeon AU -金,Jeong-Min AU -李,Seung-Hoon TI -特征和临床意义的白质病变患者的成人烟雾病- 10.1212 / WNL援助。0000000000207130 DP - 2023年3月06 TA -神经病半岛投注体育官网学PG - 10.1212 / WNL。0000000000207130 4099 - http://n.半岛投注体育官网neurology.org/content/early/2023/03/06/WNL.0000000000207130.short 4100 - //www.ebmtp.com/content/early/2023/03/06/WNL.0000000000207130.full AB -背景和ObjectivesWhite hyperintensities(负责人)据报道,增加性烟雾病(MMD);然而,他们的临床重要性并不完善的由于其病理生理异质性分布。本研究旨在评估负责人的负担和模式在多党民主运动轨迹及其临床意义。MethodsAdult多党民主运动没有重大结构性病变患者与健康对照组1:1倾向score-matched性和血管危险因素。总、室,皮层下负责人卷自动分割和量化完全。研究负责人卷被年龄去趋势两组之间的比较。多党民主运动基于铃木阶段和未来缺血性事件严重程度与负责人进行了评估卷。ResultsA共有161对患者多党民主运动和控制进行了分析。多党民主运动与负责人总额增加显著相关(B(标准误差),0.126 (0.030);术;0.001)、室负责人卷(0.114 [0.027]; p<0.001), and periventricular-to-subcortical ratio (0.090 [0.034]; p=0.009). In the MMD subgroup (n=187), advanced MMD had an independent positive association with the total WMH volume (0.120 [0.035]; p<0.001), periventricular WMH volume (0.110 [0.031]; p<0.001), and periventricular-to-subcortical ratio (0.139 [0.038]; p<0.001). Periventricular WMH volume (adjusted hazard ratio [95% confidence interval], 5.12 [1.26–20.79]) and periventricular-to-subcortical ratio (3.80 [1.51–9.56]) were associated with future ischemic events in medically followed-up MMD patients. However, no demonstrable association was found between subcortical WMH volume and MMD, MMD severity, or future ischemic events.DiscussionPeriventricular WMH, but not subcortical WMH, may represent the main pathophysiology of MMD. Periventricular WMH may be used as a marker for ischemic vulnerability in patients with MMD.

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