杂志文章%A Mielke, Michelle M. %A Frank, Ryan D. %A Christenson, Luke R . A Fields, Julie A. A Rocca, Walter A. A Garovic, Vesna D. T妊娠高血压疾病与晚年认知的关系%D 2023 %R 10.1212/WNL。0000000000207134% J神半岛投注体育官网经学%P 10.1212/WNL。妊娠期高血压疾病(HDP)的研究，包括妊娠期或慢性高血压(GH/CH)和先兆子痫/子痫(PE/E)，提示与早期和中年认知有关，但由于自我报告或诊断代码的使用，排除了未生育妇女，以及缺乏对晚年认知的测量，这些研究受到了限制。我们检查了任何HDP、GH/CH、PE/E和nulliparity对晚年认知的影响。研究对象包括2239名女性(中位年龄73岁)，她们参加了梅奥诊所老年研究，并有妊娠信息的医疗记录。每15个月进行9项认知测试。整体认知和特定领域的z得分(记忆、执行/注意力、视觉空间、语言)是结果。线性混合效应模型评估了怀孕史(所有正常血压、任何HPD、HPD亚型[GH/CH, PE/E]或未生育)与年龄和教育调整后的认知能力下降之间的相关性。附加模型调整了载脂蛋白e、吸烟、高血压、血脂异常、身体质量指数(BMI)、糖尿病、中风和心脏病。研究了怀孕史与年龄或教育程度对认知能力的影响。结果2239例女性中，1854例(82.8%)至少怀孕一次(1607例血压正常，GH/CH 100例，PE/E 147例); 385 (17.2%) were nulliparous. Cognitive performance did not cross-sectionally differ for women with a history of any HDP, GH/CH, or PE/E versus women with a history of all normotensive pregnancies; women who were nulliparous had lower global and domain-specific cognition (all p<0.05) in age- and education-adjusted models. There was an interaction (p=0.015) between nulliparity and education such that the lower cognitive performance was most pronounced among nulliparous women with ≤12 years of education (beta = -0.42, p<0.001) versus 12+ years (b = -0.11, p=0.049). Longitudinally, women with any HDP had greater declines in global cognition and attention/executive z-scores compared to women with all normotensive pregnancies. When stratified by HDP type, only women with PE/E had greater declines in global cognition (beta = -0.04, p<0.001), language (beta = -0.03, p=0.001), and attention (beta = -0.04, p<0.001) z-scores. Adjustment for vascular risk factors, BMI, smoking, and APOE did not attenuate results.Discussion Women with a history of HDP, especially PE/E, are at greater risk of cognitive decline in later life. %U //www.ebmtp.com/content/neurology/early/2023/03/01/WNL.0000000000207134.full.pdf