RT杂志文章SR电子T1他汀类药物使用与脑出血位置的相关性JF神经学JO神经学FD Lippincott Williams & Wilkins SP e1048 OP e1061 DO 10.1212/WNL.000半岛投注体育官网0000000201664VO 100 IS 10 A1 Boe, Nils Jensen A1 Hald, Stine Munk A1 Jensen, Mie Micheelsen A1 Bojsen, Jonas Asgaard A1 Elhakim, Mohammad Talal A1 Florisson, Sandra A1 Saleh, Alisa A1 Clausen, Anne A1 Möller, Sören A1 Harbo, Frederik Severin Gråe A1 Graumann, Ole A1 Hallas, Jesper A1 García Rodríguez, Luis Alberto A1 Al-Shahi Salman, Rustam A1 Goldstein, Larry B. A1 Gaist，David YR 2023 UL http://n.半岛投注体育官网neurology.org/content/100/10/e1048.abstract AB背景和目的他汀类药物使用与脑出血(ICH)之间的因果关系尚不确定。我们假设长期他汀类药物暴露与ICH风险之间的关联可能因不同的ICH位置而有所不同。方法:我们使用丹麦全国范围内的相关登记进行了分析。在丹麦南部地区(人口120万)，我们确定了2009年至2018年间年龄≥55岁的所有首次脑出血病例。经医疗记录证实诊断的患者被分为大叶性脑出血或非大叶性脑出血，并在年龄、性别和日历年方面与一般人群对照相匹配。我们使用全国处方注册表来确定之前使用他汀类药物和其他药物，并根据最近时间、持续时间和强度进行分类。使用对潜在混杂因素进行调整的条件logistic回归，我们计算了大叶性和非大叶性脑出血风险的调整ORs (aORs)和相应的95% ci。结果:我们确定了989例大叶性脑出血患者(52.2%为女性，平均年龄76.3岁)与39500名对照者匹配，1175例非大叶性脑出血患者(46.5%为女性，平均年龄75.1岁)与46755名对照者匹配。目前使用他汀类药物与大叶病变风险降低相关(aOR 0.83; 95% CI, 0.70–0.98) and nonlobar ICH (aOR 0.84; 95% CI, 0.72–0.98). Longer duration of statin use was also associated with a lower risk of lobar (<1 year: aOR 0.89; 95% CI, 0.69–1.14; ≥1 year to <5 years aOR 0.89; 95% CI 0.73–1.09; ≥5 years aOR 0.67; 95% CI, 0.51–0.87; p for trend 0.040) and nonlobar ICH (<1 year: aOR 1.00; 95% CI, 0.80–1.25; ≥1 year to <5 years aOR 0.88; 95% CI 0.73–1.06; ≥5 years aOR 0.62; 95% CI, 0.48–0.80; p for trend <0.001). Estimates stratified by statin intensity were similar to the main estimates for low-medium intensity therapy (lobar aOR 0.82; nonlobar aOR 0.84); the association with high-intensity therapy was neutral.Discussion We found that statin use was associated with a lower risk of ICH, particularly with longer treatment duration. This association did not vary by hematoma location.aOR=adjusted OR; CAA=cerebral amyloid angiopathy; ICH=intracerebral hemorrhage; IVH=intraventricular hemorrhage; RSD=Region of Southern Denmark; SVD=small vessel disease

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